ENSG00000163629


Homo sapiens

Features
Gene ID: ENSG00000163629
  
Biological name :PTPN13
  
Synonyms : protein tyrosine phosphatase, non-receptor type 13 / PTPN13 / Q12923
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q21.3
Gene start: 86594315
Gene end: 86815171
  
Corresponding Affymetrix probe sets: 204201_s_at (Human Genome U133 Plus 2.0 Array)   243792_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422835
Ensembl peptide - ENSP00000408368
Ensembl peptide - ENSP00000423531
Ensembl peptide - ENSP00000426626
Ensembl peptide - ENSP00000322675
Ensembl peptide - ENSP00000394794
Ensembl peptide - ENSP00000407249
NCBI entrez gene - 5783     See in Manteia.
OMIM - 600267
RefSeq - XM_017008516
RefSeq - NM_080685
RefSeq - XM_011532165
RefSeq - XM_017008511
RefSeq - XM_017008512
RefSeq - XM_017008513
RefSeq - XM_017008514
RefSeq - XM_017008515
RefSeq - NM_006264
RefSeq - NM_080683
RefSeq - NM_080684
RefSeq Peptide - NP_542416
RefSeq Peptide - NP_006255
RefSeq Peptide - NP_542414
RefSeq Peptide - NP_542415
swissprot - Q12923
swissprot - D6R9X4
swissprot - D6R9M4
Ensembl - ENSG00000163629
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn13ENSDARG00000103699Danio rerio
 PTPN13ENSGALG00000011078Gallus gallus
 Ptpn13ENSMUSG00000034573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FRMPD2 / Q68DX3 / FERM and PDZ domain containing 2ENSG0000017032419
PTPN14 / Q15678 / protein tyrosine phosphatase, non-receptor type 14ENSG0000015210412
PTPN21 / Q16825 / protein tyrosine phosphatase, non-receptor type 21ENSG0000007077812
FRMD6 / Q96NE9 / FERM domain containing 6ENSG000001399266
FRMD1 / Q8N878 / FERM domain containing 1ENSG000001533035


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011019  KIND domain
 IPR011993  PH-like domain superfamily
 IPR012153  Tyrosine-protein phosphatase non-receptor type 13
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR029906  FERM and PDZ domain-containing protein 2
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily
 IPR036085  PAZ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IMP
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107679 Q9HB21 / PLEKHA1 / pleckstrin homology domain containing A1  / complex






 

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