ENSG00000070778


Homo sapiens

Features
Gene ID: ENSG00000070778
  
Biological name :PTPN21
  
Synonyms : protein tyrosine phosphatase, non-receptor type 21 / PTPN21 / Q16825
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q31.3
Gene start: 88465778
Gene end: 88554733
  
Corresponding Affymetrix probe sets: 1320_at (Human Genome U133 Plus 2.0 Array)   205438_at (Human Genome U133 Plus 2.0 Array)   222092_at (Human Genome U133 Plus 2.0 Array)   226380_at (Human Genome U133 Plus 2.0 Array)   40524_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443951
Ensembl peptide - ENSP00000451401
Ensembl peptide - ENSP00000452414
Ensembl peptide - ENSP00000330276
Ensembl peptide - ENSP00000450847
NCBI entrez gene - 11099     See in Manteia.
OMIM - 603271
RefSeq - XM_017020939
RefSeq - XM_006720011
RefSeq - XM_011536367
RefSeq - XM_011536368
RefSeq - XM_011536369
RefSeq - XM_017020938
RefSeq - NM_007039
RefSeq - XM_005267287
RefSeq Peptide - NP_008970
swissprot - G3V3S6
swissprot - H0YJ59
swissprot - G3V1Q9
swissprot - Q16825
Ensembl - ENSG00000070778
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn21ENSDARG00000062248Danio rerio
 PTPN21ENSGALG00000010616Gallus gallus
 Ptpn21ENSMUSG00000021009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN14 / Q15678 / protein tyrosine phosphatase, non-receptor type 14ENSG0000015210455
PTPN13 / Q12923 / protein tyrosine phosphatase, non-receptor type 13ENSG0000016362926
FRMPD2 / Q68DX3 / FERM and PDZ domain containing 2ENSG0000017032413
FRMD6 / Q96NE9 / FERM domain containing 6ENSG000001399269
FRMD1 / Q8N878 / FERM domain containing 1ENSG000001533037


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014392  Protein-tyrosine phosphatase, non-receptor type-14, -21
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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