ENSDARG00000062248


Danio rerio

Features
Gene ID: ENSDARG00000062248
  
Biological name :ptpn21
  
Synonyms : protein tyrosine phosphatase, non-receptor type 21 / ptpn21
  
Possible biological names infered from orthology : Q16825
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 2606697
Gene end: 2690083
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000144576
Ensembl peptide - ENSDARP00000155480
Ensembl peptide - ENSDARP00000115700
NCBI entrez gene - 799627     See in Manteia.
RefSeq - XM_001339926
swissprot - A0A286YBL8
swissprot - F1Q6T9
ZFIN ID - ZDB-GENE-080102-4
Ensembl - ENSDARG00000062248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPN21ENSGALG00000010616Gallus gallus
 PTPN21ENSG00000070778Homo sapiens
 Ptpn21ENSMUSG00000021009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptpn13 / protein tyrosine phosphatase, non-receptor type 13 / Q12923*ENSDARG0000010369911
frmpd2 / FERM and PDZ domain containing 2 / Q68DX3*ENSDARG000000741199
frmd6 / FERM domain containing 6 / Q8C0V9* / Q96NE9* / FERM domain-containing protein 6 *ENSDARG000000023329
zgc:172136 / FRMD1* / Q8N878* / FERM domain containing 1*ENSDARG000000787417
si:ch73-205h11.1 / FRMD1* / Q8N878* / FERM domain containing 1*ENSDARG000000967576
ptpn20 / protein tyrosine phosphatase, non-receptor type 20ENSDARG000000754595
CR931802.3ENSDARG000001062451


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014392  Protein-tyrosine phosphatase, non-receptor type-14, -21
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart decreased size , abnormal
heart edematous , abnormal
Show

 ZFA:0001083 ventricular zone ventricular zone increased size , abnormal
ventricular zone cell increased mass density , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch decreased length , abnormal
pharyngeal arch cell increased mass density , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
Show

 ZFA:0001462 somite border somite border irregular spatial pattern , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve non-functional , abnormal
Show

 ZFA:0009044 blood cell blood cell aggregated , abnormal
Show

 ZFA:0009091 melanocyte melanocyte mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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