ENSMUSG00000026700


Mus musculus

Features
Gene ID: ENSMUSG00000026700
  
Biological name :Tnfsf4
  
Synonyms : P43488 / Tnfsf4 / Tumor necrosis factor ligand superfamily member 4
  
Possible biological names infered from orthology : P23510 / TNF superfamily member 4
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.1
Gene start: 161395409
Gene end: 161418410
  
Corresponding Affymetrix probe sets: 10351095 (MoGene1.0st)   1421744_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028024
NCBI entrez gene - 22164     See in Manteia.
MGI - MGI:104511
RefSeq - NM_009452
RefSeq Peptide - NP_033478
swissprot - B6DXE3
swissprot - P43488
Ensembl - ENSMUSG00000026700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P23510ENSG00000117586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development NAS
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0002215 defense response to nematode IMP
 biological_processGO:0002526 acute inflammatory response IMP
 biological_processGO:0002699 positive regulation of immune effector process TAS
 biological_processGO:0002726 positive regulation of T cell cytokine production IDA
 biological_processGO:0002819 regulation of adaptive immune response IDA
 biological_processGO:0002830 positive regulation of type 2 immune response IMP
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response IMP
 biological_processGO:0006954 inflammatory response IPI
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032700 negative regulation of interleukin-17 production ISS
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032736 positive regulation of interleukin-13 production IDA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0035709 memory T cell activation IMP
 biological_processGO:0035712 T-helper 2 cell activation IMP
 biological_processGO:0035713 response to nitrogen dioxide IDA
 biological_processGO:0035714 cellular response to nitrogen dioxide IMP
 biological_processGO:0035783 CD4-positive, alpha-beta T cell costimulation IDA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation IDA
 biological_processGO:0043382 positive regulation of memory T cell differentiation IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation IMP
 biological_processGO:0045626 negative regulation of T-helper 1 cell differentiation IDA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0050710 negative regulation of cytokine secretion IPI
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050871 positive regulation of B cell activation IDA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IDA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IC
 biological_processGO:0070236 negative regulation of activation-induced cell death of T cells IC
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071380 cellular response to prostaglandin E stimulus ISS
 biological_processGO:0071954 chemokine (C-C motif) ligand 11 production IMP
 biological_processGO:1900281 positive regulation of CD4-positive, alpha-beta T cell costimulation IDA
 biological_processGO:2000406 positive regulation of T cell migration NAS
 biological_processGO:2000525 positive regulation of T cell costimulation IDA
 biological_processGO:2000568 positive regulation of memory T cell activation IMP
 biological_processGO:2000570 positive regulation of T-helper 2 cell activation IMP
 biological_processGO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IC
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IPI


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Tnfsf4Ath1-C57BL/6J/Tnfsf4Ath1-C57BL/6J,Ath2C57BL/6J/Ath2C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Tnfsf4Ath1-BALB/cJ/?
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Tnfsf4Ath1-A/J/Tnfsf4Ath1-A/J,Ath2A/J/Ath2A/J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-C57BL/6J
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-C57BL/6J
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: St14tm1Bug/St14tm1Bug
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: involves: 129S4/SvJae

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Athsq3C3H/HeJ/Athsq3C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Tnfsf4Ath1-C57BL/6J/Tnfsf4Ath1-C57BL/6J,Ath2C57BL/6J/Ath2C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Tnfsf4Ath1-BALB/cJ/?
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Tnfsf4Ath1-A/J/Tnfsf4Ath1-A/J,Ath2A/J/Ath2A/J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: involves: 129S4/SvJae

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029075 Tnfrsf4 / tumor necrosis factor receptor superfamily, member 4 / P43489* / TNF receptor superfamily member 4*  / reaction / complex
 ENSMUSG00000026700 P43488 / Tnfsf4 / Tumor necrosis factor ligand superfamily member 4 / P23510* / TNF superfamily member 4*  / complex






 

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