ENSG00000117586


Homo sapiens

Features
Gene ID: ENSG00000117586
  
Biological name :TNFSF4
  
Synonyms : P23510 / TNFSF4 / TNF superfamily member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q25.1
Gene start: 173183734
Gene end: 173207313
  
Corresponding Affymetrix probe sets: 207426_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356691
Ensembl peptide - ENSP00000281834
NCBI entrez gene - 7292     See in Manteia.
OMIM - 603594
RefSeq - XM_017002230
RefSeq - NM_001297562
RefSeq - NM_003326
RefSeq - XM_011509964
RefSeq - XM_017002229
RefSeq Peptide - NP_001284491
RefSeq Peptide - NP_003317
swissprot - P23510
swissprot - A0A024R937
Ensembl - ENSG00000117586
  
Related genetic diseases (OMIM): 608446 - {Myocardial infarction, susceptibility to}, 608446
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P43488ENSMUSG00000026700Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002215 defense response to nematode ISS
 biological_processGO:0002526 acute inflammatory response ISS
 biological_processGO:0002726 positive regulation of T cell cytokine production ISS
 biological_processGO:0002819 regulation of adaptive immune response ISS
 biological_processGO:0002830 positive regulation of type 2 immune response ISS
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response ISS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009615 response to virus ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production ISS
 biological_processGO:0032700 negative regulation of interleukin-17 production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032736 positive regulation of interleukin-13 production ISS
 biological_processGO:0032753 positive regulation of interleukin-4 production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0035709 memory T cell activation ISS
 biological_processGO:0035712 T-helper 2 cell activation ISS
 biological_processGO:0035713 response to nitrogen dioxide ISS
 biological_processGO:0042102 positive regulation of T cell proliferation IBA
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
 biological_processGO:0043382 positive regulation of memory T cell differentiation ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0045590 negative regulation of regulatory T cell differentiation ISS
 biological_processGO:0045626 negative regulation of T-helper 1 cell differentiation ISS
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation ISS
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0050871 positive regulation of B cell activation ISS
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 biological_processGO:0071954 chemokine (C-C motif) ligand 11 production ISS
 biological_processGO:1900281 positive regulation of CD4-positive, alpha-beta T cell costimulation ISS
 biological_processGO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IBA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000504 Abnormality of vision "Abnormality of eyesight (visual perception)." [HPO:curators]
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 HP:0000738 Hallucinations 
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 HP:0001279 Syncope "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. This term refers to an abnormally increased disposition to syncope." [HPO:curators]
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 HP:0001350 Slurred speech 
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 HP:0001513 Obesity "A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY)." [MeSH:D009765]
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 HP:0002189 Excessive daytime sleepiness 
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 HP:0002494 Abnormal rapid eye movement (REM) sleep "Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements." [HPO:curators]
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 HP:0002524 Cataplexy 
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 HP:0010534 Transient global amnesia "A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117586 P23510 / TNFSF4 / TNF superfamily member 4  / complex
 ENSG00000186827 P43489 / TNFRSF4 / TNF receptor superfamily member 4  / reaction / complex






 

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