ENSMUSG00000026790


Mus musculus

Features
Gene ID: ENSMUSG00000026790
  
Biological name :Odf2
  
Synonyms : A3KGV1 / Mus musculus outer dense fiber of sperm tails 2 (Odf2), transcript variant 6, mRNA. / Odf2
  
Possible biological names infered from orthology : outer dense fiber of sperm tails 2 / Q5BJF6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 29889221
Gene end: 29931746
  
Corresponding Affymetrix probe sets: 10470788 (MoGene1.0st)   1426040_a_at (Mouse Genome 430 2.0 Array)   1435216_a_at (Mouse Genome 430 2.0 Array)   1439918_at (Mouse Genome 430 2.0 Array)   1444101_at (Mouse Genome 430 2.0 Array)   1454735_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109396
Ensembl peptide - ENSMUSP00000109394
Ensembl peptide - ENSMUSP00000117628
Ensembl peptide - ENSMUSP00000139390
Ensembl peptide - ENSMUSP00000121207
Ensembl peptide - ENSMUSP00000117887
Ensembl peptide - ENSMUSP00000028128
Ensembl peptide - ENSMUSP00000049272
Ensembl peptide - ENSMUSP00000109384
Ensembl peptide - ENSMUSP00000109385
Ensembl peptide - ENSMUSP00000109386
Ensembl peptide - ENSMUSP00000109388
Ensembl peptide - ENSMUSP00000109391
Ensembl peptide - ENSMUSP00000109392
Ensembl peptide - ENSMUSP00000109393
NCBI entrez gene - 18286     See in Manteia.
MGI - MGI:1098824
RefSeq - XM_017316306
RefSeq - XM_017316286
RefSeq - XM_017316288
RefSeq - XM_017316289
RefSeq - XM_017316290
RefSeq - XM_017316291
RefSeq - XM_017316292
RefSeq - XM_017316293
RefSeq - XM_017316294
RefSeq - XM_017316295
RefSeq - XM_017316299
RefSeq - XM_017316300
RefSeq - XM_017316301
RefSeq - XM_017316304
RefSeq - XM_017316305
RefSeq - NM_001113213
RefSeq - NM_001113214
RefSeq - NM_001177659
RefSeq - NM_001177661
RefSeq - NM_001355136
RefSeq - NM_013615
RefSeq - XM_017316272
RefSeq - XM_017316273
RefSeq - XM_017316275
RefSeq - XM_017316276
RefSeq - XM_017316279
RefSeq - XM_017316280
RefSeq - XM_017316281
RefSeq - XM_017316283
RefSeq - XM_017316284
RefSeq - XM_017316285
RefSeq Peptide - NP_001171130
RefSeq Peptide - NP_001171132
RefSeq Peptide - NP_001342065
RefSeq Peptide - NP_001342066
RefSeq Peptide - NP_038643
RefSeq Peptide - NP_001106684
RefSeq Peptide - NP_001106685
swissprot - A3KGV1
swissprot - A3KGV9
swissprot - A3KGV3
swissprot - F6Y325
swissprot - A3KGV2
swissprot - A3KGW0
swissprot - V9GXZ0
Ensembl - ENSMUSG00000026790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 odf2aENSDARG00000028900Danio rerio
 odf2bENSDARG00000020702Danio rerio
 ODF2ENSGALG00000004767Gallus gallus
 ODF2ENSG00000136811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Odf2l / Q9D478 / Outer dense fiber protein 2-like / Q9ULJ1* / outer dense fiber of sperm tails 2 like*ENSMUSG0000002825619


Protein motifs (from Interpro)
Interpro ID Name
 IPR026099  Outer dense fibre protein 2-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0010457 centriole-centriole cohesion ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:1902017 regulation of cilium assembly ISO
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0001520 outer dense fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097539 ciliary transition fiber IDA
 cellular_componentGO:0120103 centriolar subdistal appendage ISO
 molecular_functionGO:0005200 structural constituent of cytoskeleton TAS
 molecular_functionGO:0017137 Rab GTPase binding ISO


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Liasnehe/Liastm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Liasnehe/Liastm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Odf2tm1.2Sats/Odf2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001950 abnormal respiratory sounds "anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004131 abnormal embryonic ciliary morphology "any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
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Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
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Allelic Composition: Odf2Gt(XL169)Byg/Odf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011053 decreased respiratory motile cilia number "reduced number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011082 abnormal gastrointestinal motility "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011644 abnormal oviduct epithelium motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct" [MGI:csmith]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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