ENSMUSG00000026791


Mus musculus

Features
Gene ID: ENSMUSG00000026791
  
Biological name :Slc2a8
  
Synonyms : Q9JIF3 / Slc2a8 / solute carrier family 2, (facilitated glucose transporter), member 8
  
Possible biological names infered from orthology : Q9NY64 / solute carrier family 2 member 8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32972990
Gene end: 32982083
  
Corresponding Affymetrix probe sets: 10481759 (MoGene1.0st)   1450628_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141959
Ensembl peptide - ENSMUSP00000142100
Ensembl peptide - ENSMUSP00000141969
Ensembl peptide - ENSMUSP00000028129
Ensembl peptide - ENSMUSP00000141879
NCBI entrez gene - 56017     See in Manteia.
MGI - MGI:1860103
RefSeq - NM_019488
RefSeq Peptide - NP_062361
swissprot - Q2TK27
swissprot - A0A0A6YXF7
swissprot - Q9JIF3
swissprot - A0A0A6YX81
swissprot - Q2TK26
Ensembl - ENSMUSG00000026791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc2a8ENSDARG00000104278Danio rerio
 SLC2A8ENSGALG00000000853Gallus gallus
 Q9NY64ENSG00000136856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc2a6 / solute carrier family 2 (facilitated glucose transporter), member 6 / Q9UGQ3* / solute carrier family 2 member 6*ENSMUSG0000003606743
Q3UHK1 / Slc2a13 / solute carrier family 2 (facilitated glucose transporter), member 13 / Q96QE2* / solute carrier family 2 member 13*ENSMUSG0000003629831
Q8BFW9 / Slc2a12 / solute carrier family 2 (facilitated glucose transporter), member 12 / Q8TD20* / solute carrier family 2 member 12*ENSMUSG0000003749029
Q8VHD6 / Slc2a10 / solute carrier family 2 (facilitated glucose transporter), member 10 / O95528* / solute carrier family 2 member 10*ENSMUSG0000002766128


Protein motifs (from Interpro)
Interpro ID Name
 IPR003663  Sugar/inositol transporter
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0015755 fructose transmembrane transport ISO
 biological_processGO:0015757 galactose transmembrane transport ISO
 biological_processGO:0046323 glucose import IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005351 carbohydrate:proton symporter activity IBA
 molecular_functionGO:0005354 galactose transmembrane transporter activity ISO
 molecular_functionGO:0005355 glucose transmembrane transporter activity IDA
 molecular_functionGO:0005536 glucose binding IDA
 molecular_functionGO:0015284 fructose uniporter activity ISO
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0001668 abnormal fructose absorption "anomalous ability of the body to take in this 5-carbon sugar" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall1tm4.1Ryn/Sall1tm4.1Ryn,Sall4tm3Ryn/Sall4tm4Ryn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall1tm4.1Ryn/Sall1tm4.1Ryn,Sall4tm3Ryn/Sall4tm4Ryn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sall1tm4.1Ryn/Sall1tm4.1Ryn,Sall4tm3Ryn/Sall4tm4Ryn
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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