Manteia

ENSMUSG00000026810

Mus musculus

Features

Gene ID:	ENSMUSG00000026810

Biological name :	Dpm2

Synonyms :	Dolichol phosphate-mannose biosynthesis regulatory protein / Dpm2 / Q9Z324

Possible biological names infered from orthology :	dolichyl-phosphate mannosyltransferase subunit 2, regulatory / O94777

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	B
Gene start:	32570858
Gene end:	32573579

Corresponding Affymetrix probe sets:	10471438 (MoGene1.0st) 10338283 (MoGene1.0st) 10342145 (MoGene1.0st) 10342295 (MoGene1.0st) 10343405 (MoGene1.0st) 10343601 (MoGene1.0st) 10344042 (MoGene1.0st) 1415675_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124665 Ensembl peptide - ENSMUSP00000028151 NCBI entrez gene - 13481 See in Manteia. MGI - MGI:1330238 RefSeq - NM_010073 RefSeq Peptide - NP_034203 swissprot - E0CXW3 swissprot - Q545R7 swissprot - Q9Z324 Ensembl - ENSMUSG00000026810

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR009914	Dolichol phosphate-mannose biosynthesis regulatory

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006486	protein glycosylation	IEA
biological_process	GO:0006506	GPI anchor biosynthetic process	IEA
biological_process	GO:0019348	dolichol metabolic process	IBA
biological_process	GO:0031647	regulation of protein stability	IEA
biological_process	GO:0035269	protein O-linked mannosylation	IBA
biological_process	GO:0050790	regulation of catalytic activity	IEA
biological_process	GO:0097502	mannosylation	IEA
cellular_component	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	ISO
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005789	endoplasmic reticulum membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	ISM
cellular_component	GO:0030176	integral component of endoplasmic reticulum membrane	IEA
cellular_component	GO:0033185	dolichol-phosphate-mannose synthase complex	IBA
molecular_function	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016757	transferase activity, transferring glycosyl groups	IEA
molecular_function	GO:0030234	enzyme regulator activity	IBA

Pathways (from Reactome)

Pathway description

Synthesis of dolichyl-phosphate mannose

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dnase1l2^{tm1.1(KOMP)Wtsi}/Dnase1l2^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Dnase1l2^{tm1.1(KOMP)Wtsi}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000042737	Dpm3 / Q9D1Q4 / Dolichol-phosphate mannosyltransferase subunit 3 / Q9P2X0* / dolichyl-phosphate mannosyltransferase subunit 3*	/ complex
ENSMUSG00000078919	Dpm1 / O70152 / Dolichol-phosphate mannosyltransferase subunit 1 / O60762* / dolichyl-phosphate mannosyltransferase subunit 1, catalytic*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr