ENSMUSG00000026827


Mus musculus

Features
Gene ID: ENSMUSG00000026827
  
Biological name :Gpd2
  
Synonyms : glycerol phosphate dehydrogenase 2, mitochondrial / Gpd2 / Q64521
  
Possible biological names infered from orthology : glycerol-3-phosphate dehydrogenase 2 / P43304
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.1
Gene start: 57237635
Gene end: 57370719
  
Corresponding Affymetrix probe sets: 10472162 (MoGene1.0st)   1417434_at (Mouse Genome 430 2.0 Array)   1428323_at (Mouse Genome 430 2.0 Array)   1452741_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130992
Ensembl peptide - ENSMUSP00000028167
Ensembl peptide - ENSMUSP00000108237
NCBI entrez gene - 14571     See in Manteia.
MGI - MGI:99778
RefSeq - NM_001145820
RefSeq - NM_010274
RefSeq Peptide - NP_001139292
RefSeq Peptide - NP_034404
swissprot - A2AQR0
swissprot - Q64521
Ensembl - ENSMUSG00000026827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpd2ENSDARG00000062430Danio rerio
 GPD2ENSGALG00000012543Gallus gallus
 GPD2ENSG00000115159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000447  FAD-dependent glycerol-3-phosphate dehydrogenase
 IPR002048  EF-hand domain
 IPR006076  FAD dependent oxidoreductase
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR031656  Alpha-glycerophosphate oxidase, C-terminal
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006072 glycerol-3-phosphate metabolic process IMP
 biological_processGO:0006094 gluconeogenesis IMP
 biological_processGO:0019563 glycerol catabolic process IEA
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0009331 glycerol-3-phosphate dehydrogenase complex TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity IEA
 molecular_functionGO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Triglyceride catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0005472 abnormal triiodothyronine level "aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009301 decreased parametrial fat pad weight 
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka,Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic Background: B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: B6.Cg-Gpd2tm1Tka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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