ENSMUSG00000026858


Mus musculus

Features
Gene ID: ENSMUSG00000026858
  
Biological name :Miga2
  
Synonyms : Miga2 / Mitoguardin 2 / Q8BK03
  
Possible biological names infered from orthology : Q7L4E1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 30364233
Gene end: 30385521
  
Corresponding Affymetrix probe sets: 10471018 (MoGene1.0st)   1420040_at (Mouse Genome 430 2.0 Array)   1433493_at (Mouse Genome 430 2.0 Array)   1449714_at (Mouse Genome 430 2.0 Array)   1454621_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135812
Ensembl peptide - ENSMUSP00000135519
Ensembl peptide - ENSMUSP00000135644
Ensembl peptide - ENSMUSP00000077127
Ensembl peptide - ENSMUSP00000097787
Ensembl peptide - ENSMUSP00000118253
Ensembl peptide - ENSMUSP00000135126
NCBI entrez gene - 108958     See in Manteia.
MGI - MGI:1922035
RefSeq - XM_006497595
RefSeq - NM_001242407
RefSeq - NM_175392
RefSeq - XM_006497593
RefSeq - XM_006497594
RefSeq Peptide - NP_001229336
RefSeq Peptide - NP_780601
swissprot - H3BLJ3
swissprot - H3BJU3
swissprot - Q8BK03
swissprot - H3BL42
swissprot - A2AWJ1
Ensembl - ENSMUSG00000026858
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 miga2ENSDARG00000089357Danio rerio
 MIGA2ENSGALG00000032342Gallus gallus
 MIGA2ENSG00000148343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Miga1 / Q4QQM5 / Mitoguardin 1 / Q8NAN2*ENSMUSG0000005494239


Protein motifs (from Interpro)
Interpro ID Name
 IPR019392  Mitoguardin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0060348 bone development IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026858 Miga2 / Q8BK03 / Mitoguardin 2 / Q7L4E1*  / complex
 ENSMUSG00000054942 Miga1 / Q4QQM5 / Mitoguardin 1 / Q8NAN2*  / complex






 

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