ENSMUSG00000054942


Mus musculus

Features
Gene ID: ENSMUSG00000054942
  
Biological name :Miga1
  
Synonyms : Miga1 / Mitoguardin 1 / Q4QQM5
  
Possible biological names infered from orthology : Q8NAN2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H3
Gene start: 152273849
Gene end: 152340407
  
Corresponding Affymetrix probe sets: 10502845 (MoGene1.0st)   1434404_at (Mouse Genome 430 2.0 Array)   1437002_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072836
Ensembl peptide - ENSMUSP00000143643
Ensembl peptide - ENSMUSP00000143238
Ensembl peptide - ENSMUSP00000143008
Ensembl peptide - ENSMUSP00000142667
Ensembl peptide - ENSMUSP00000068261
NCBI entrez gene - 215708     See in Manteia.
MGI - MGI:1924567
RefSeq - XM_011240070
RefSeq - NM_001162375
RefSeq - NM_174868
RefSeq Peptide - NP_001155847
RefSeq Peptide - NP_777357
swissprot - B2RRB9
swissprot - A0A0G2JGP3
swissprot - A0A0G2JE80
swissprot - A0A0G2JF36
swissprot - Q4QQM5
Ensembl - ENSMUSG00000054942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 miga1ENSDARG00000020596Danio rerio
 MIGA1ENSGALG00000008951Gallus gallus
 MIGA1ENSG00000180488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Miga2 / Q8BK03 / Mitoguardin 2 / Q7L4E1*ENSMUSG0000002685839


Protein motifs (from Interpro)
Interpro ID Name
 IPR019392  Mitoguardin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008053 mitochondrial fusion IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0005387 immune system phenotype 
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054942 Miga1 / Q4QQM5 / Mitoguardin 1 / Q8NAN2*  / complex
 ENSMUSG00000026858 Miga2 / Q8BK03 / Mitoguardin 2 / Q7L4E1*  / complex






 

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contact: otassy@igbmc.fr