Manteia - Molecule gene

ENSMUSG00000026922

Mus musculus

Features

Gene ID:	ENSMUSG00000026922

Biological name :	Agpat2

Synonyms :	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) / Agpat2 / Q8K3K7

Possible biological names infered from orthology :	1-acylglycerol-3-phosphate O-acyltransferase 2 / O15120

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	A3
Gene start:	26593057
Gene end:	26604417

Corresponding Affymetrix probe sets:	10481092 (MoGene1.0st) 1428821_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028286 Ensembl peptide - ENSMUSP00000115059 NCBI entrez gene - 67512 See in Manteia. MGI - MGI:1914762 RefSeq - XM_017319222 RefSeq - NM_026212 RefSeq Peptide - NP_080488 swissprot - Q059U0 swissprot - Q8K3K7 swissprot - A2AI22 Ensembl - ENSMUSG00000026922

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
agpat2	ENSDARG00000101139	Danio rerio
AGPAT2	ENSGALG00000023517	Gallus gallus
AGPAT2	ENSG00000169692	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Agpat1 / 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) / Q99943* / 1-acylglycerol-3-phosphate O-acyltransferase 1*	ENSMUSG00000034254	44

Protein motifs (from Interpro)

Interpro ID	Name
IPR002123	Phospholipid/glycerol acyltransferase
IPR004552	1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001819	positive regulation of cytokine production	IEA
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006654	phosphatidic acid biosynthetic process	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0008544	epidermis development	IEA
biological_process	GO:0008654	phospholipid biosynthetic process	NAS
biological_process	GO:0016024	CDP-diacylglycerol biosynthetic process	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0046474	glycerophospholipid biosynthetic process	IBA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	ISO
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016746	transferase activity, transferring acyl groups	IEA

Pathways (from Reactome)

Pathway description

Synthesis of PA

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000010	abnormal abdominal fat pads	"malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0000129	ameloblast degeneration	"a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Atg4b^{Gt(OST264114)Lex}/Atg4b^{Gt(OST264114)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Atg4b^{Gt(OST264114)Lex}/Atg4b^{Gt(OST264114)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atg4b^{Gt(OST264114)Lex}/Atg4b^{Gt(OST264114)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0001426	polydipsia	"excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atg4b^{Gt(OST264114)Lex}/Atg4b^{Gt(OST264114)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0002500	granulomatous inflammation	"chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002577	reduced enamel thickness	"thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0002971	abnormal brown fat morphology	"defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0003645	increased number of pancreatic beta cells	"greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0003948	abnormal gas homeostasis	"anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0004777	abnormal phospholipid level	"anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005280	abnormal fatty acid level	"anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0005358	abnormal incisor morphology	"structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0008843	absent subcutaneous adipose tissue	"absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0008963	increased carbon dioxide production	"increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0009113	increased pancreatic beta cell mass	"greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0009117	abnormal white fat cell morphology	"any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009131	decreased white fat cell number	"reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009171	enlarged pancreatic islets	"increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0010179	rough coat	"coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0011174	lipodystrophy	"abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg,Mogat1^tm1Far/Mogat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Lmx1a^dr/Lmx1a^dr Genetic Background: Not Specified
MP:0013249	adipose tissue necrosis	"morphological changes resulting from pathological death of adipose tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0020386	adipose tissue inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0030542	abnormal dentin development	"any anomaly in the process whose specific outcome is the formation of dentin, the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root; dentinogenesis begins prior to enamel formation and is initiated by the odontoblasts of the dental pulp; dentin is derived from the dental papilla of the tooth germ; after apposition of predentin and maturation into dentin, the cell bodies of the odontoblasts remain in the pulp inside the tooth, along its outer wall; unlike enamel, dentin continues to form throughout life and can be initiated in response to stimuli, such as tooth decay or attrition" [GO:0097187, https://en.wikipedia.org/wiki/Dentin]	Show Allelic Composition: Agpat2^{Gt(OST438470)Lex}/Agpat2^{Gt(OST438470)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr