ENSMUSG00000027006


Mus musculus

Features
Gene ID: ENSMUSG00000027006
  
Biological name :Dnajc10
  
Synonyms : Dnajc10 / DnaJ homolog subfamily C member 10 / Q9DC23
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member C10 / Q8IXB1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 80315466
Gene end: 80354043
  
Corresponding Affymetrix probe sets: 10473190 (MoGene1.0st)   1426904_s_at (Mouse Genome 430 2.0 Array)   1426905_a_at (Mouse Genome 430 2.0 Array)   1452230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028392
NCBI entrez gene - 66861     See in Manteia.
MGI - MGI:1914111
RefSeq - NM_024181
RefSeq Peptide - NP_077143
swissprot - Q9DC23
Ensembl - ENSMUSG00000027006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajc10ENSDARG00000074727Danio rerio
 DNAJC10ENSGALG00000008862Gallus gallus
 Q8IXB1ENSG00000077232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91W90 / Txndc5 / thioredoxin domain containing 5 / Q8NBS9*ENSMUSG0000003899114
Pdia6 / protein disulfide isomerase associated 6 / Q15084* / protein disulfide isomerase family A member 6*ENSMUSG0000002057113
Pdia5 / Q921X9 / Protein disulfide-isomerase A5 / Q14554* / protein disulfide isomerase family A member 5*ENSMUSG0000002284413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR021170  DnaJ homologue subfamily C member 10
 IPR035673  ERdj5, first thioredoxin domain
 IPR035674  ERdj5, C-terminal thioredoxin domain
 IPR036249  Thioredoxin-like superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0032781 positive regulation of ATPase activity IMP
 biological_processGO:0034975 protein folding in endoplasmic reticulum ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen ISO
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IEA
 molecular_functionGO:0001671 ATPase activator activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0015036 disulfide oxidoreductase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IDA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0012322 decreased total tissue mass "decreased physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue" [MPD:Molly]
Show

Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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