ENSMUSG00000038991


Mus musculus

Features
Gene ID: ENSMUSG00000038991
  
Biological name :Txndc5
  
Synonyms : Q91W90 / thioredoxin domain containing 5 / Txndc5
  
Possible biological names infered from orthology : Q8NBS9
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 38500079
Gene end: 38528824
  
Corresponding Affymetrix probe sets: 10408741 (MoGene1.0st)   1423746_at (Mouse Genome 430 2.0 Array)   1451091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124516
Ensembl peptide - ENSMUSP00000041839
Ensembl peptide - ENSMUSP00000124401
NCBI entrez gene - 105245     See in Manteia.
MGI - MGI:2145316
RefSeq - NM_001289598
RefSeq - NM_001289599
RefSeq - NM_145367
RefSeq Peptide - NP_001276528
RefSeq Peptide - NP_001276527
RefSeq Peptide - NP_663342
swissprot - Q3TEE8
swissprot - A0A0R4J1Y7
swissprot - Q91W90
swissprot - E9PXX7
Ensembl - ENSMUSG00000038991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txndc5ENSDARG00000009342Danio rerio
 TXNDC5ENSGALG00000012784Gallus gallus
 Q8NBS9ENSG00000239264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DC23 / Dnajc10 / DnaJ homolog subfamily C member 10 / Q8IXB1* / DnaJ heat shock protein family (Hsp40) member C10*ENSMUSG0000002700626
Pdia5 / Q921X9 / Protein disulfide-isomerase A5 / Q14554* / protein disulfide isomerase family A member 5*ENSMUSG0000002284426
Pdia6 / protein disulfide isomerase associated 6 / Q15084* / protein disulfide isomerase family A member 6*ENSMUSG0000002057122


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IBA
 biological_processGO:0034976 response to endoplasmic reticulum stress IBA
 biological_processGO:0043277 apoptotic cell clearance IBA
 biological_processGO:0045454 cell redox homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IBA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Txndc5tm1.1(KOMP)Vlcg/Txndc5tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Txndc5tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Txndc5tm1.1(KOMP)Vlcg/Txndc5tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Txndc5tm1.1(KOMP)Vlcg/Ucd

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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