ENSG00000077232


Homo sapiens

Features
Gene ID: ENSG00000077232
  
Biological name :DNAJC10
  
Synonyms : DNAJC10 / DnaJ heat shock protein family (Hsp40) member C10 / Q8IXB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q32.1
Gene start: 182716041
Gene end: 182794464
  
Corresponding Affymetrix probe sets: 221781_s_at (Human Genome U133 Plus 2.0 Array)   221782_at (Human Genome U133 Plus 2.0 Array)   225174_at (Human Genome U133 Plus 2.0 Array)   229588_at (Human Genome U133 Plus 2.0 Array)   243635_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441560
Ensembl peptide - ENSP00000491817
Ensembl peptide - ENSP00000481044
Ensembl peptide - ENSP00000479930
Ensembl peptide - ENSP00000264065
Ensembl peptide - ENSP00000389483
Ensembl peptide - ENSP00000400096
NCBI entrez gene - 54431     See in Manteia.
OMIM - 607987
RefSeq - NM_018981
RefSeq - NM_001271581
RefSeq Peptide - NP_001258510
RefSeq Peptide - NP_061854
swissprot - Q8IXB1
swissprot - A0A087WXH7
swissprot - H7C1G0
swissprot - Q71S60
swissprot - E7EP04
Ensembl - ENSG00000077232
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajc10ENSDARG00000074727Danio rerio
 DNAJC10ENSGALG00000008862Gallus gallus
 Q9DC23ENSMUSG00000027006Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NBS9 / TXNDC5 / thioredoxin domain containing 5ENSG0000023926414
PDIA6 / Q15084 / protein disulfide isomerase family A member 6ENSG0000014387013
PDIA5 / Q14554 / protein disulfide isomerase family A member 5ENSG0000006548513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR021170  DnaJ homologue subfamily C member 10
 IPR035673  ERdj5, first thioredoxin domain
 IPR035674  ERdj5, C-terminal thioredoxin domain
 IPR036249  Thioredoxin-like superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0032781 positive regulation of ATPase activity ISS
 biological_processGO:0034975 protein folding in endoplasmic reticulum IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 molecular_functionGO:0001671 ATPase activator activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity ISS
 molecular_functionGO:0015036 disulfide oxidoreductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISS
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0051087 chaperone binding IDA
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:0051787 misfolded protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr