ENSMUSG00000027170


Mus musculus

Features
Gene ID: ENSMUSG00000027170
  
Biological name :Eif3m
  
Synonyms : Eif3m / Eukaryotic translation initiation factor 3 subunit M / Q99JX4
  
Possible biological names infered from orthology : Q7L2H7
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 104999656
Gene end: 105017080
  
Corresponding Affymetrix probe sets: 10353475 (MoGene1.0st)   10485635 (MoGene1.0st)   1437189_x_at (Mouse Genome 430 2.0 Array)   1451076_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028592
Ensembl peptide - ENSMUSP00000122339
Ensembl peptide - ENSMUSP00000106739
NCBI entrez gene - 98221     See in Manteia.
MGI - MGI:1351744
RefSeq - NM_145380
RefSeq Peptide - NP_663355
swissprot - A2A702
swissprot - A2A701
swissprot - Q99JX4
Ensembl - ENSMUSG00000027170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif3mENSDARG00000013931Danio rerio
 EIF3MENSGALG00000012109Gallus gallus
 EIF3MENSG00000149100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR027528  Eukaryotic translation initiation factor 3 subunit M
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002183 cytoplasmic translational initiation IBA
 biological_processGO:0006412 translation IMP
 biological_processGO:0006413 translational initiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex ISO
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IDA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IDA


Pathways (from Reactome)
Pathway description
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Eif3mtm1Nju/Eif3mtm1Nju,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Eif3mtm1Nju/Eif3mtm1Nju,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Eif3mtm1.1Nju/Eif3m+
Genetic Background: involves: 129 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3mtm1Nju/Eif3mtm1Nju,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * FVB/N

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3mtm1.1Nju/Eif3m+
Genetic Background: involves: 129 * FVB/N

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Eif3mtm1.1Nju/Eif3m+
Genetic Background: involves: 129 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Eif3mtm1Nju/Eif3mtm1Nju,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * FVB/N

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif3mtm1.1Nju/Eif3m+
Genetic Background: involves: 129 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Eif3mtm1Nju/Eif3mtm1Nju,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr