ENSMUSG00000027185


Mus musculus

Features
Gene ID: ENSMUSG00000027185
  
Biological name :Nat10
  
Synonyms : Nat10 / Q8K224 / RNA cytidine acetyltransferase
  
Possible biological names infered from orthology : N-acetyltransferase 10 / Q9H0A0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 103721256
Gene end: 103761270
  
Corresponding Affymetrix probe sets: 10485483 (MoGene1.0st)   1433692_at (Mouse Genome 430 2.0 Array)   1447601_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028608
Ensembl peptide - ENSMUSP00000129637
Ensembl peptide - ENSMUSP00000115072
NCBI entrez gene - 98956     See in Manteia.
MGI - MGI:2138939
RefSeq - NM_153126
RefSeq - XM_006500455
RefSeq Peptide - NP_694766
swissprot - E9Q498
swissprot - Q8K224
swissprot - A2BH46
Ensembl - ENSMUSG00000027185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nat10ENSDARG00000054259Danio rerio
 NAT10ENSGALG00000014573Gallus gallus
 NAT10ENSG00000135372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR007807  Helicase domain
 IPR013562  tRNA(Met) cytidine acetyltransferase TmcA, N-terminal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR027992  Possible tRNA binding domain
 IPR032672  TmcA/NAT10/Kre33
 IPR033688  RNA cytidine acetyltransferase NAT10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002101 tRNA wobble cytosine modification IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0016072 rRNA metabolic process IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0034470 ncRNA processing IEA
 biological_processGO:0051391 tRNA acetylation IBA
 biological_processGO:1904812 rRNA acetylation involved in maturation of SSU-rRNA IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030686 90S preribosome IBA
 molecular_functionGO:0000049 tRNA binding IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0051392 tRNA N-acetyltransferase activity IBA
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:1990883 rRNA cytidine N-acetyltransferase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0012767 increased KLRG1-positive NK cell number "increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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