ENSMUSG00000027254


Mus musculus

Features
Gene ID: ENSMUSG00000027254
  
Biological name :Map1a
  
Synonyms : Map1a / Microtubule-associated protein 1A MAP1A heavy chain MAP1 light chain LC2 / Q9QYR6
  
Possible biological names infered from orthology : microtubule associated protein 1A / P78559
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 121289600
Gene end: 121310832
  
Corresponding Affymetrix probe sets: 10475314 (MoGene1.0st)   1455779_at (Mouse Genome 430 2.0 Array)   1460566_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092223
Ensembl peptide - ENSMUSP00000106269
NCBI entrez gene - 17754     See in Manteia.
MGI - MGI:1306776
RefSeq - XM_006498872
RefSeq - NM_001173506
RefSeq - NM_032393
RefSeq Peptide - NP_001166977
RefSeq Peptide - NP_115769
swissprot - Q9QYR6
swissprot - A2ARP8
Ensembl - ENSMUSG00000027254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map1aaENSDARG00000059601Danio rerio
 map1abENSDARG00000022045Danio rerio
 ENSGALG00000035587Gallus gallus
 ENSGALG00000008425Gallus gallus
 MAP1AENSG00000166963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map1b / P14873 / microtubule-associated protein 1B / P46821*ENSMUSG0000005272727
Map1s / Q8C052 / Microtubule-associated protein 1S MAP1S heavy chain MAP1S light chain / Q66K74* / microtubule associated protein 1S*ENSMUSG0000001926113


Protein motifs (from Interpro)
Interpro ID Name
 IPR015656  Microtubule associated protein 1A
 IPR026074  Microtubule associated protein 1
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0007605 sensory perception of sound IDA
 biological_processGO:0045494 photoreceptor cell maintenance IGI
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Map1am1J/Map1atm1.2(KOMP)Mbp
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Map1am1J/Map1atm1.2(KOMP)Mbp
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Map1am1J/Map1atm1.2(KOMP)Mbp
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0010733 abnormal axon initial segment morphology "any structural anomaly of the short unmyelinated axon segment adjacent to the cell soma where voltage gated channels accumulate and axon potential initiation usually occurs" [PMID:18929652]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7+,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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