ENSMUSG00000027272


Mus musculus

Features
Gene ID: ENSMUSG00000027272
  
Biological name :Ubr1
  
Synonyms : O70481 / ubiquitin protein ligase E3 component n-recognin 1 / Ubr1
  
Possible biological names infered from orthology : Q8IWV7
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 120860269
Gene end: 120970715
  
Corresponding Affymetrix probe sets: 10486616 (MoGene1.0st)   1420971_at (Mouse Genome 430 2.0 Array)   1446438_at (Mouse Genome 430 2.0 Array)   1450066_at (Mouse Genome 430 2.0 Array)   1458033_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028728
NCBI entrez gene - 22222     See in Manteia.
MGI - MGI:1277977
RefSeq - XM_006499165
RefSeq - NM_009461
RefSeq - XM_006499164
RefSeq Peptide - NP_033487
swissprot - O70481
Ensembl - ENSMUSG00000027272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018474.1ENSDARG00000104306Danio rerio
 ubr1ENSDARG00000060480Danio rerio
 UBR1ENSGALG00000009249Gallus gallus
 UBR1ENSG00000159459Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ubr2 / Q6WKZ8 / ubiquitin protein ligase E3 component n-recognin 2 / Q8IWV8*ENSMUSG0000002397747
Ubr3 / Q5U430 / ubiquitin protein ligase E3 component n-recognin 3 / Q6ZT12* / ubiquitin protein ligase E3 component n-recognin 3 (putative)*ENSMUSG0000004430819


Protein motifs (from Interpro)
Interpro ID Name
 IPR003126  Zinc finger, UBR-type
 IPR003769  Adaptor protein ClpS, core
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014719  Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0071233 cellular response to leucine IEA
 biological_processGO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
 cellular_componentGO:0000151 ubiquitin ligase complex IGI
 cellular_componentGO:0000502 proteasome complex IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0070728 leucine binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003999 improved passive avoidance behavior "increase in the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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