ENSMUSG00000023977


Mus musculus

Features
Gene ID: ENSMUSG00000023977
  
Biological name :Ubr2
  
Synonyms : Q6WKZ8 / ubiquitin protein ligase E3 component n-recognin 2 / Ubr2
  
Possible biological names infered from orthology : Q8IWV8
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46928295
Gene end: 47010556
  
Corresponding Affymetrix probe sets: 10451495 (MoGene1.0st)   1427163_at (Mouse Genome 430 2.0 Array)   1429515_at (Mouse Genome 430 2.0 Array)   1429516_at (Mouse Genome 430 2.0 Array)   1453878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108961
Ensembl peptide - ENSMUSP00000108963
Ensembl peptide - ENSMUSP00000152895
NCBI entrez gene - 224826     See in Manteia.
MGI - MGI:1861099
RefSeq - XM_006524145
RefSeq - NM_001177374
RefSeq - NM_146078
RefSeq Peptide - NP_001170845
RefSeq Peptide - NP_666190
swissprot - Q3UPU3
swissprot - Q6WKZ8
swissprot - A0A286YCB2
Ensembl - ENSMUSG00000023977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ubr2ENSDARG00000070164Danio rerio
 UBR2ENSGALG00000009906Gallus gallus
 UBR2ENSG00000024048Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ubr1 / O70481 / ubiquitin protein ligase E3 component n-recognin 1 / Q8IWV7*ENSMUSG0000002727247
Ubr3 / Q5U430 / ubiquitin protein ligase E3 component n-recognin 3 / Q6ZT12* / ubiquitin protein ligase E3 component n-recognin 3 (putative)*ENSMUSG0000004430819


Protein motifs (from Interpro)
Interpro ID Name
 IPR003126  Zinc finger, UBR-type
 IPR003769  Adaptor protein ClpS, core
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014719  Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007131 reciprocal meiotic recombination IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0033522 histone H2A ubiquitination IDA
 biological_processGO:0071233 cellular response to leucine ISO
 biological_processGO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
 cellular_componentGO:0000151 ubiquitin ligase complex IGI
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IGI
 molecular_functionGO:0070728 leucine binding ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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