ENSG00000024048


Homo sapiens

Features
Gene ID: ENSG00000024048
  
Biological name :UBR2
  
Synonyms : Q8IWV8 / ubiquitin protein ligase E3 component n-recognin 2 / UBR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 42564062
Gene end: 42693504
  
Corresponding Affymetrix probe sets: 1569140_at (Human Genome U133 Plus 2.0 Array)   212756_s_at (Human Genome U133 Plus 2.0 Array)   212760_at (Human Genome U133 Plus 2.0 Array)   215558_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361990
Ensembl peptide - ENSP00000361992
Ensembl peptide - ENSP00000361994
NCBI entrez gene - 23304     See in Manteia.
OMIM - 609134
RefSeq - XM_017010597
RefSeq - NM_001184801
RefSeq - NM_015255
RefSeq - XM_017010594
RefSeq - XM_017010595
RefSeq - XM_017010596
RefSeq - XM_005248965
RefSeq - XM_005248966
RefSeq - XM_011514438
RefSeq - XM_011514439
RefSeq - XM_011514440
RefSeq - XM_011514441
RefSeq Peptide - NP_056070
RefSeq Peptide - NP_001171730
swissprot - Q8IWV8
Ensembl - ENSG00000024048
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ubr2ENSDARG00000070164Danio rerio
 UBR2ENSGALG00000009906Gallus gallus
 Ubr2ENSMUSG00000023977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBR1 / Q8IWV7 / ubiquitin protein ligase E3 component n-recognin 1ENSG0000015945947
UBR3 / Q6ZT12 / ubiquitin protein ligase E3 component n-recognin 3 (putative)ENSG0000014435720


Protein motifs (from Interpro)
Interpro ID Name
 IPR003126  Zinc finger, UBR-type
 IPR003769  Adaptor protein ClpS, core
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014719  Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007131 reciprocal meiotic recombination ISS
 biological_processGO:0007140 male meiotic nuclear division ISS
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0033522 histone H2A ubiquitination IBA
 biological_processGO:0071233 cellular response to leucine IDA
 biological_processGO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0070728 leucine binding IDA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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