ENSMUSG00000027452


Mus musculus

Features
Gene ID: ENSMUSG00000027452
  
Biological name :Acss1
  
Synonyms : Acetyl-coenzyme A synthetase 2-like, mitochondrial / Acss1 / Q99NB1
  
Possible biological names infered from orthology : acyl-CoA synthetase short chain family member 1 / Q9NUB1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 150618105
Gene end: 150668500
  
Corresponding Affymetrix probe sets: 10488482 (MoGene1.0st)   1416617_at (Mouse Genome 430 2.0 Array)   1437582_at (Mouse Genome 430 2.0 Array)   1437583_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028944
NCBI entrez gene - 68738     See in Manteia.
MGI - MGI:1915988
RefSeq - NM_080575
RefSeq Peptide - NP_542142
swissprot - Q3UJ89
swissprot - Q99NB1
Ensembl - ENSMUSG00000027452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acss1ENSDARG00000044142Danio rerio
 ACSS1ENSGALG00000008632Gallus gallus
 ACSS1ENSG00000154930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acss2 / Q9QXG4 / Acetyl-coenzyme A synthetase, cytoplasmic / Q9NR19* / acyl-CoA synthetase short chain family member 2*ENSMUSG0000002760546
Acss3 / Q14DH7 / Acyl-CoA synthetase short-chain family member 3, mitochondrial / Q9H6R3* / acyl-CoA synthetase short chain family member 3*ENSMUSG0000003594834
Acsm5 / Q8BGA8 / Acyl-coenzyme A synthetase ACSM5, mitochondrial / Q6NUN0* / acyl-CoA synthetase medium chain family member 5*ENSMUSG0000003097224
Acsm4 / Q80W40 / Acyl-coenzyme A synthetase ACSM4, mitochondrial / P0C7M7* / acyl-CoA synthetase medium chain family member 4*ENSMUSG0000004702623
Acsm2 / Q8K0L3 / Acyl-coenzyme A synthetase ACSM2, mitochondrial / ACSM2B* / Q68CK6* / ACSM2A* / Q08AH3* / acyl-CoA synthetase medium chain family member 2B* / acyl-CoA synthetase medium c...ENSMUSG0000003094522
Acsm3 / Q3UNX5 / Acyl-coenzyme A synthetase ACSM3, mitochondrial / Q53FZ2* / acyl-CoA synthetase medium chain family member 3*ENSMUSG0000003093522
Acsm1 / Q91VA0 / Acyl-coenzyme A synthetase ACSM1, mitochondrial / Q08AH1* / acyl-CoA synthetase medium chain family member 1*ENSMUSG0000003353322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR011904  Acetate-CoA ligase
 IPR020845  AMP-binding, conserved site
 IPR025110  AMP-binding enzyme, C-terminal domain
 IPR032387  Acetyl-coenzyme A synthetase, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006085 acetyl-CoA biosynthetic process ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019413 acetate biosynthetic process IEA
 biological_processGO:0019427 acetyl-CoA biosynthetic process from acetate IEA
 biological_processGO:0019542 propionate biosynthetic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003987 acetate-CoA ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016208 AMP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003860 abnormal carbon dioxide level "anomalous concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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