ENSMUSG00000027454


Mus musculus

Features
Gene ID: ENSMUSG00000027454
  
Biological name :Gins1
  
Synonyms : DNA replication complex GINS protein PSF1 / Gins1 / Q9CZ15
  
Possible biological names infered from orthology : GINS complex subunit 1 / Q14691
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 150905400
Gene end: 150931280
  
Corresponding Affymetrix probe sets: 10476989 (MoGene1.0st)   1452598_at (Mouse Genome 430 2.0 Array)   1457981_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028948
NCBI entrez gene - 69270     See in Manteia.
MGI - MGI:1916520
RefSeq - XM_006500133
RefSeq - NM_001163476
RefSeq - NM_027014
RefSeq Peptide - NP_081290
RefSeq Peptide - NP_001156948
swissprot - Q9CZ15
Ensembl - ENSMUSG00000027454
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gins1ENSDARG00000007624Danio rerio
 GINS1ENSGALG00000008538Gallus gallus
 GINS1ENSG00000101003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005339  GINS complex, subunit Psf1
 IPR036224  GINS, helical bundle-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:1902983 DNA strand elongation involved in mitotic DNA replication IBA
 cellular_componentGO:0000811 GINS complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043138 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
Unwinding of DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031546 Gins4 / Q99LZ3 / DNA replication complex GINS protein SLD5 DNA replication complex GINS protein SLD5, N-terminally processed / Q9BRT9* / GINS complex subunit 4*  / complex / reaction
 ENSMUSG00000031821 Gins2 / Q9D600 / DNA replication complex GINS protein PSF2 / Q9Y248* / GINS complex subunit 2*  / complex / reaction
 ENSMUSG00000031669 Gins3 / Q9CY94 / DNA replication complex GINS protein PSF3 / Q9BRX5* / GINS complex subunit 3*  / complex / reaction






 

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