ENSMUSG00000031546


Mus musculus

Features
Gene ID: ENSMUSG00000031546
  
Biological name :Gins4
  
Synonyms : DNA replication complex GINS protein SLD5 DNA replication complex GINS protein SLD5, N-terminally processed / Gins4 / Q99LZ3
  
Possible biological names infered from orthology : GINS complex subunit 4 / Q9BRT9
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 23226616
Gene end: 23237659
  
Corresponding Affymetrix probe sets: 10577623 (MoGene1.0st)   1417913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033950
NCBI entrez gene - 109145     See in Manteia.
MGI - MGI:1923847
RefSeq - NM_024240
RefSeq Peptide - NP_077202
swissprot - Q99LZ3
Ensembl - ENSMUSG00000031546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gins4ENSDARG00000016044Danio rerio
 GINS4ENSGALG00000045374Gallus gallus
 GINS4ENSG00000147536Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008591  GINS complex subunit Sld5
 IPR021151  GINS subunit, domain A
 IPR031633  DNA replication complex GINS protein SLD5, C-terminal
 IPR036224  GINS, helical bundle-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000727 double-strand break repair via break-induced replication IBA
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0000811 GINS complex IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031298 replication fork protection complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043138 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
Unwinding of DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0012113 decreased inner cell mass proliferation 
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Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0012743 increased inner cell mass apoptosis "increased number of cells of the blastocyst that develop into the body of the embryo undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Raph1tm1.1Makr/Raph1tm1.1Makr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031821 Gins2 / Q9D600 / DNA replication complex GINS protein PSF2 / Q9Y248* / GINS complex subunit 2*  / reaction / complex
 ENSMUSG00000027454 Gins1 / Q9CZ15 / DNA replication complex GINS protein PSF1 / Q14691* / GINS complex subunit 1*  / complex / reaction
 ENSMUSG00000031669 Gins3 / Q9CY94 / DNA replication complex GINS protein PSF3 / Q9BRX5* / GINS complex subunit 3*  / reaction / complex






 

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