ENSMUSG00000027531


Mus musculus

Features
Gene ID: ENSMUSG00000027531
  
Biological name :Impa1
  
Synonyms : Impa1 / inositol (myo)-1(or 4)-monophosphatase 1
  
Possible biological names infered from orthology : inositol monophosphatase 1 / P29218
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 10311956
Gene end: 10331439
  
Corresponding Affymetrix probe sets: 10497285 (MoGene1.0st)   1423127_at (Mouse Genome 430 2.0 Array)   1430495_at (Mouse Genome 430 2.0 Array)   1436848_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141345
Ensembl peptide - ENSMUSP00000068174
Ensembl peptide - ENSMUSP00000113860
Ensembl peptide - ENSMUSP00000116088
NCBI entrez gene - 55980     See in Manteia.
MGI - MGI:1933158
RefSeq - XM_006530078
RefSeq - NM_001310433
RefSeq - NM_018864
RefSeq - XM_006530077
RefSeq Peptide - NP_001297362
RefSeq Peptide - NP_061352
swissprot - Q80ZJ2
swissprot - D3Z703
swissprot - Q924B0
swissprot - A0A0A6YW07
Ensembl - ENSMUSG00000027531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 impa1ENSDARG00000003517Danio rerio
 IMPA1ENSGALG00000034487Gallus gallus
 IMPA1ENSG00000133731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Impa2 / Q91UZ5 / inositol (myo)-1(or 4)-monophosphatase 2 / O14732* / inositol monophosphatase 2*ENSMUSG0000002452552


Protein motifs (from Interpro)
Interpro ID Name
 IPR000760  Inositol monophosphatase-like
 IPR020550  Inositol monophosphatase, conserved site
 IPR020552  Inositol monophosphatase, Lithium-sensitive
 IPR020583  Inositol monophosphatase, metal-binding site
 IPR033942  Inositol monophosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006021 inositol biosynthetic process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0006796 phosphate-containing compound metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0008934 inositol monophosphate 1-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0031403 lithium ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052832 inositol monophosphate 3-phosphatase activity IEA
 molecular_functionGO:0052833 inositol monophosphate 4-phosphatase activity IEA
 molecular_functionGO:0052834 inositol monophosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009849 increased vertical stereotypic behavior "increase in the frequency of vertical crossings (greater than one per second)" [PMID:19720087]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027531 Impa1 / inositol (myo)-1(or 4)-monophosphatase 1 / P29218* / inositol monophosphatase 1*  / complex






 

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