ENSMUSG00000024525


Mus musculus

Features
Gene ID: ENSMUSG00000024525
  
Biological name :Impa2
  
Synonyms : Impa2 / inositol (myo)-1(or 4)-monophosphatase 2 / Q91UZ5
  
Possible biological names infered from orthology : inositol monophosphatase 2 / O14732
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 67289253
Gene end: 67319146
  
Corresponding Affymetrix probe sets: 10456383 (MoGene1.0st)   1418665_at (Mouse Genome 430 2.0 Array)   1459983_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025403
NCBI entrez gene - 114663     See in Manteia.
MGI - MGI:2149728
RefSeq - NM_053261
RefSeq Peptide - NP_444491
swissprot - Q3U3B7
swissprot - Q91UZ5
Ensembl - ENSMUSG00000024525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 impa2ENSDARG00000059411Danio rerio
 IMPA2ENSGALG00000013814Gallus gallus
 IMPA2ENSG00000141401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Impa1 / inositol (myo)-1(or 4)-monophosphatase 1 / P29218* / inositol monophosphatase 1*ENSMUSG0000002753149


Protein motifs (from Interpro)
Interpro ID Name
 IPR000760  Inositol monophosphatase-like
 IPR020550  Inositol monophosphatase, conserved site
 IPR020552  Inositol monophosphatase, Lithium-sensitive
 IPR020583  Inositol monophosphatase, metal-binding site
 IPR033942  Inositol monophosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006020 inositol metabolic process TAS
 biological_processGO:0006021 inositol biosynthetic process IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008934 inositol monophosphate 1-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052832 inositol monophosphate 3-phosphatase activity IEA
 molecular_functionGO:0052833 inositol monophosphate 4-phosphatase activity IEA
 molecular_functionGO:0052834 inositol monophosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024525 Impa2 / Q91UZ5 / inositol (myo)-1(or 4)-monophosphatase 2 / O14732* / inositol monophosphatase 2*  / complex






 

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