ENSMUSG00000027794


Mus musculus

Features
Gene ID: ENSMUSG00000027794
  
Biological name :Sohlh2
  
Synonyms : Q9D489 / Sohlh2 / Spermatosis- and oosis-specific basic helix-loop-helix-containing protein 2
  
Possible biological names infered from orthology : CCDC169-SOHLH2 / CCDC169-SOHLH2 readthrough / Q9NX45 / spermatogenesis and oogenesis specific basic helix-loop-helix 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 55182028
Gene end: 55209957
  
Corresponding Affymetrix probe sets: 10492123 (MoGene1.0st)   1429817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029369
NCBI entrez gene - 74434     See in Manteia.
MGI - MGI:1921684
RefSeq - NM_028937
RefSeq Peptide - NP_083213
swissprot - Q9D489
Ensembl - ENSMUSG00000027794
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCDC169-SOHLH2ENSG00000250709Homo sapiens
 Q9NX45ENSG00000120669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR032669  Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001545 primary ovarian follicle growth IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IDA
 biological_processGO:0009994 oocyte differentiation IDA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048477 oogenesis IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Efemp2tm1.1Chu/Efemp2+
Genetic Background: B6(SJL)-Efemp2tm1.1Chu

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Efemp2tm1.1Chu/Efemp2+
Genetic Background: B6(SJL)-Efemp2tm1.1Chu

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
Show

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011125 decreased primary ovarian follicle number "fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
Show

Allelic Composition: Sohlh2tm1Rajk/Sohlh2tm1Rajk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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