ENSMUSG00000027977


Mus musculus

Features
Gene ID: ENSMUSG00000027977
  
Biological name :Ndst3
  
Synonyms : N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 / Ndst3 / Q9EQH7
  
Possible biological names infered from orthology : N-deacetylase and N-sulfotransferase 3 / O95803
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 123526166
Gene end: 123690853
  
Corresponding Affymetrix probe sets: 10501924 (MoGene1.0st)   1443277_at (Mouse Genome 430 2.0 Array)   1453777_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029602
Ensembl peptide - ENSMUSP00000120623
Ensembl peptide - ENSMUSP00000133657
Ensembl peptide - ENSMUSP00000122617
Ensembl peptide - ENSMUSP00000118207
Ensembl peptide - ENSMUSP00000118796
NCBI entrez gene - 83398     See in Manteia.
MGI - MGI:1932544
RefSeq - XM_006502371
RefSeq - XM_006502370
RefSeq - NM_001293682
RefSeq - NM_031186
RefSeq - XM_006502376
RefSeq Peptide - NP_112463
RefSeq Peptide - NP_001280611
swissprot - Q9EQH7
swissprot - E9PZJ4
swissprot - D3YXE5
Ensembl - ENSMUSG00000027977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndst3ENSDARG00000041776Danio rerio
 ENSGALG00000038525Gallus gallus
 ENSGALG00000046333Gallus gallus
 ENSGALG00000012010Gallus gallus
 NDST3ENSG00000164100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndst4 / Q9EQW8 / Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 Heparan sulfate N-deacetylase 4 Heparan sulfate N-sulfotransferase 4 / Q9H3R1* / N-deacetylase and N-sulfotr...ENSMUSG0000002797180
Ndst1 / Q3UHN9 / Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Heparan sulfate N-deacetylase 1 Heparan sulfate N-sulfotransferase 1 / P52848* / N-deacetylase and N-sulfotr...ENSMUSG0000005400870
Ndst2 / P52850 / N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 / P52849* / AC022400.6* / N-deacetylase and N-sulfotransferase 2* / bifunctional heparan sulfate N-deacetylase/N-s...ENSMUSG0000003930865
Hs3st4 / heparan sulfate-glucosamine 3-sulfotransferase 4 / Q9Y661*ENSMUSG0000007859112
Q9QZS6 / Hs3st3b1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 / Q9Y662* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000007040712
Q8BKN6 / Hs3st3a1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 / Q9Y662* / HS3ST3B1* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000004775912
Hs3st2 / Q673U1 / Heparan sulfate glucosamine 3-O-sulfotransferase 2 / Q9Y278* / heparan sulfate-glucosamine 3-sulfotransferase 2*ENSMUSG0000004632111
Hs3st1 / O35310 / Heparan sulfate glucosamine 3-O-sulfotransferase 1 / O14792* / heparan sulfate-glucosamine 3-sulfotransferase 1*ENSMUSG0000005102210
Hs3st5 / Q8BSL4 / heparan sulfate (glucosamine) 3-O-sulfotransferase 5 / Q8IZT8* / heparan sulfate-glucosamine 3-sulfotransferase 5*ENSMUSG0000004449910
Hs3st6 / Q5GFD5 / Heparan sulfate glucosamine 3-O-sulfotransferase 6 / Q96QI5* / heparan sulfate-glucosamine 3-sulfotransferase 6*ENSMUSG0000003962810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR021930  Heparan sulphate-N-deacetylase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037359  Heparan sulfate sulfotransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IEA
 biological_processGO:0030210 heparin biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IDA
 molecular_functionGO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity IEA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005274 abnormal viscerocranium morphology "anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009898 maxillary shelf hypoplasia "underdevelopment, usually due to a deficiency in the number of cells, of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0010940 abnormal maxillary prominence morphology 
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0030250 frontonasal prominence hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the unpaired embryonic process that is formed from the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0030313 abnormal face development "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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