ENSMUSG00000039308


Mus musculus

Features
Gene ID: ENSMUSG00000039308
  
Biological name :Ndst2
  
Synonyms : N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 / Ndst2 / P52850
  
Possible biological names infered from orthology : AC022400.6 / bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2 / N-deacetylase and N-sulfotransferase 2 / P52849
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 20723730
Gene end: 20734562
  
Corresponding Affymetrix probe sets: 10417950 (MoGene1.0st)   1417931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153393
Ensembl peptide - ENSMUSP00000040227
Ensembl peptide - ENSMUSP00000153036
Ensembl peptide - ENSMUSP00000153141
Ensembl peptide - ENSMUSP00000153275
NCBI entrez gene - 17423     See in Manteia.
MGI - MGI:97040
RefSeq - XM_011244981
RefSeq - XM_011244982
RefSeq - NM_010811
RefSeq Peptide - NP_034941
swissprot - P52850
swissprot - A0A286YDF1
swissprot - Q2TBA8
Ensembl - ENSMUSG00000039308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndst2aENSDARG00000086269Danio rerio
 ndst2bENSDARG00000060678Danio rerio
 ENSGALG00000005107Gallus gallus
 AC022400.6ENSG00000272916Homo sapiens
 NDST2ENSG00000166507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndst1 / Q3UHN9 / Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Heparan sulfate N-deacetylase 1 Heparan sulfate N-sulfotransferase 1 / P52848* / N-deacetylase and N-sulfotr...ENSMUSG0000005400871
Ndst4 / Q9EQW8 / Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 Heparan sulfate N-deacetylase 4 Heparan sulfate N-sulfotransferase 4 / Q9H3R1* / N-deacetylase and N-sulfotr...ENSMUSG0000002797165
Ndst3 / Q9EQH7 / N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 / O95803* / N-deacetylase and N-sulfotransferase 3*ENSMUSG0000002797765
Q8BKN6 / Hs3st3a1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 / Q9Y662* / HS3ST3B1* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000004775913
Q9QZS6 / Hs3st3b1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 / Q9Y662* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000007040712
Hs3st4 / heparan sulfate-glucosamine 3-sulfotransferase 4 / Q9Y661*ENSMUSG0000007859112
Hs3st5 / Q8BSL4 / heparan sulfate (glucosamine) 3-O-sulfotransferase 5 / Q8IZT8* / heparan sulfate-glucosamine 3-sulfotransferase 5*ENSMUSG0000004449911
Hs3st2 / Q673U1 / Heparan sulfate glucosamine 3-O-sulfotransferase 2 / Q9Y278* / heparan sulfate-glucosamine 3-sulfotransferase 2*ENSMUSG0000004632111
Hs3st1 / O35310 / Heparan sulfate glucosamine 3-O-sulfotransferase 1 / O14792* / heparan sulfate-glucosamine 3-sulfotransferase 1*ENSMUSG0000005102210
Hs3st6 / Q5GFD5 / Heparan sulfate glucosamine 3-O-sulfotransferase 6 / Q96QI5* / heparan sulfate-glucosamine 3-sulfotransferase 6*ENSMUSG0000003962810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR021930  Heparan sulphate-N-deacetylase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037359  Heparan sulfate sulfotransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002002 regulation of angiotensin levels in blood IMP
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009987 cellular process IMP
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IMP
 biological_processGO:0030210 heparin biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008146 sulfotransferase activity IDA
 molecular_functionGO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IDA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndst2tm1Lkj/Ndst2tm1Lkj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ffar1tm1Heed/Ffar1tm1Heed
Genetic Background: Not Specified

 MP:0000361 reduced mast cell protease storage "decreased amounts of proteolytic enzymes stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ndst2tm1Lkj/Ndst2tm1Lkj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000362 reduced histamine storage "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ndst2tm1Lkj/Ndst2tm1Lkj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001347 absent lacrimal glands "missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ndst1tm1Grob/Ndst1tm1Grob,Ndst2tm1Lkj/Ndst2tm1Lkj,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ndst1tm1Grob/Ndst1tm1Grob,Ndst2tm1Lkj/Ndst2tm1Lkj,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Vgftm1Vlcg/Vgftm1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vgftm1Vlcg/Vgftm1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ndst2tm1Lkj/Ndst2tm1Lkj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0013331 abnormal lacrimal gland development "aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue" [MGI:Anna, PMID:22745308]
Show

Allelic Composition: Ndst1tm1Grob/Ndst1tm1Grob,Ndst2tm1Lkj/Ndst2tm1Lkj,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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