ENSMUSG00000028121


Mus musculus

Features
Gene ID: ENSMUSG00000028121
  
Biological name :Bcar3
  
Synonyms : Bcar3 / Breast cancer anti-estrogen resistance protein 3 / Q9QZK2
  
Possible biological names infered from orthology : BCAR3, NSP family adaptor protein / O75815
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 122294136
Gene end: 122530191
  
Corresponding Affymetrix probe sets: 10495781 (MoGene1.0st)   1415936_at (Mouse Genome 430 2.0 Array)   1431564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029766
Ensembl peptide - ENSMUSP00000143711
Ensembl peptide - ENSMUSP00000143112
Ensembl peptide - ENSMUSP00000142469
Ensembl peptide - ENSMUSP00000142340
NCBI entrez gene - 29815     See in Manteia.
MGI - MGI:1352501
RefSeq - XM_006501558
RefSeq - NM_013867
RefSeq Peptide - NP_038895
swissprot - A0A0G2JDE7
swissprot - A0A0G2JFC0
swissprot - A0A0G2JGV2
swissprot - Q9QZK2
swissprot - A0A0G2JDR4
Ensembl - ENSMUSG00000028121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcar3ENSDARG00000016981Danio rerio
 BCAR3ENSG00000137936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QZS8 / Sh2d3c / SH2 domain-containing protein 3C / Q8N5H7* / SH2 domain containing 3C*ENSMUSG0000005901340


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR028849  Breast cancer anti-estrogen resistance protein 3
 IPR036860  SH2 domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bcar3tm1Lern/Bcar3tm1Lern
Genetic Background: B6.129S6-Bcar3tm1Lern

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0004222 synechia "an adhesion of parts, especially involving the iris e.g. attachments of the iris to the trabecular meshwork and peripheral cornea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0005195 abnormal posterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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