ENSMUSG00000059013


Mus musculus

Features
Gene ID: ENSMUSG00000059013
  
Biological name :Sh2d3c
  
Synonyms : Q9QZS8 / Sh2d3c / SH2 domain-containing protein 3C
  
Possible biological names infered from orthology : Q8N5H7 / SH2 domain containing 3C
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 32721055
Gene end: 32755512
  
Corresponding Affymetrix probe sets: 10471505 (MoGene1.0st)   1415886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073866
Ensembl peptide - ENSMUSP00000108868
NCBI entrez gene - 27387     See in Manteia.
MGI - MGI:1351631
RefSeq - XM_017318941
RefSeq - NM_001252547
RefSeq - NM_013781
RefSeq - XM_006498095
RefSeq - XM_006498096
RefSeq Peptide - NP_001239476
RefSeq Peptide - NP_038809
swissprot - Q9QZS8
Ensembl - ENSMUSG00000059013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh2d3caENSDARG00000028099Danio rerio
 sh2d3cbENSDARG00000104555Danio rerio
 SH2D3CENSGALG00000005036Gallus gallus
 Q8N5H7ENSG00000095370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcar3 / Q9QZK2 / Breast cancer anti-estrogen resistance protein 3 / O75815* / BCAR3, NSP family adaptor protein*ENSMUSG0000002812138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036860  SH2 domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007254 JNK cascade IBA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008193 abnormal marginal zone B cell physiology "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010059 olfactory bulb hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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