ENSMUSG00000028223


Mus musculus

Features
Gene ID: ENSMUSG00000028223
  
Biological name :Decr1
  
Synonyms : 2,4-dienoyl-CoA reductase, mitochondrial / Decr1 / Q9CQ62
  
Possible biological names infered from orthology : 2,4-dienoyl-CoA reductase 1 / Q16698
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A2
Gene start: 15917240
Gene end: 15945507
  
Corresponding Affymetrix probe sets: 10511679 (MoGene1.0st)   1419367_at (Mouse Genome 430 2.0 Array)   1449443_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029877
NCBI entrez gene - 67460     See in Manteia.
MGI - MGI:1914710
RefSeq - NM_026172
RefSeq Peptide - NP_080448
swissprot - Q4FJK0
swissprot - Q9CQ62
Ensembl - ENSMUSG00000028223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 decr1ENSDARG00000003869Danio rerio
 DECR1ENSGALG00000036990Gallus gallus
 DECR1ENSG00000104325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pecr / Q99MZ7 / peroxisomal trans-2-enoyl-CoA reductase / Q9BY49*ENSMUSG0000002618927
Decr2 / Q9WV68 / Peroxisomal 2,4-dienoyl-CoA reductase / Q9NUI1* / 2,4-dienoyl-CoA reductase 2*ENSMUSG0000003677526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028223 Decr1 / Q9CQ62 / 2,4-dienoyl-CoA reductase, mitochondrial / Q16698* / 2,4-dienoyl-CoA reductase 1*  / complex






 

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