ENSMUSG00000028307


Mus musculus

Features
Gene ID: ENSMUSG00000028307
  
Biological name :Aldob
  
Synonyms : Aldob / Fructose-bisphosphate aldolase B / Q91Y97
  
Possible biological names infered from orthology : aldolase, fructose-bisphosphate B / P05062
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 49535995
Gene end: 49549546
  
Corresponding Affymetrix probe sets: 10512904 (MoGene1.0st)   1451194_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029987
NCBI entrez gene - 230163     See in Manteia.
MGI - MGI:87995
RefSeq - NM_144903
RefSeq Peptide - NP_659152
swissprot - Q3UER1
swissprot - Q91Y97
Ensembl - ENSMUSG00000028307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldobENSDARG00000053684Danio rerio
 ALDOBENSGALG00000015544Gallus gallus
 ALDOBENSG00000136872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aldoa / P05064 / Fructose-bisphosphate aldolase A / P04075* / aldolase, fructose-bisphosphate A*ENSMUSG0000003069571
Aldoc / P05063 / Fructose-bisphosphate aldolase C / P09972* / aldolase, fructose-bisphosphate C*ENSMUSG0000001739071
Aldoart1 / aldolase 1 A, retrogene 1 / ALDOA* / P04075* / aldolase, fructose-bisphosphate A*ENSMUSG0000005934371
Aldoart2 / aldolase 1 A, retrogene 2 / ALDOA* / P04075* / aldolase, fructose-bisphosphate A*ENSMUSG0000006312970


Protein motifs (from Interpro)
Interpro ID Name
 IPR000741  Fructose-bisphosphate aldolase, class-I
 IPR013785  Aldolase-type TIM barrel
 IPR029768  Fructose-bisphosphate aldolase class-I active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006096 glycolytic process ISO
 biological_processGO:0006116 NADH oxidation IEA
 biological_processGO:0030388 fructose 1,6-bisphosphate metabolic process IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0061615 glycolytic process through fructose-6-phosphate IC
 biological_processGO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
 biological_processGO:0061625 glycolytic process through fructose-1-phosphate IC
 biological_processGO:0070072 vacuolar proton-transporting V-type ATPase complex assembly ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0034451 centriolar satellite IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004332 fructose-bisphosphate aldolase activity ISO
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0061609 fructose-1-phosphate aldolase activity ISO
 molecular_functionGO:0070061 fructose binding IEA


Pathways (from Reactome)
Pathway description
Glycolysis
Gluconeogenesis
Fructose catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0008993 abnormal portal triad morphology "any structural anomaly of the three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028307 Aldob / Q91Y97 / Fructose-bisphosphate aldolase B / P05062* / aldolase, fructose-bisphosphate B*  / complex






 

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