ENSMUSG00000028312


Mus musculus

Features
Gene ID: ENSMUSG00000028312
  
Biological name :Smc2
  
Synonyms : Q8CG48 / Smc2 / Structural maintenance of chromosomes protein 2
  
Possible biological names infered from orthology : O95347 / structural maintenance of chromosomes 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B2
Gene start: 52439243
Gene end: 52488260
  
Corresponding Affymetrix probe sets: 10504957 (MoGene1.0st)   1429658_a_at (Mouse Genome 430 2.0 Array)   1429659_at (Mouse Genome 430 2.0 Array)   1429660_s_at (Mouse Genome 430 2.0 Array)   1448635_at (Mouse Genome 430 2.0 Array)   1458479_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114228
Ensembl peptide - ENSMUSP00000099979
Ensembl peptide - ENSMUSP00000113940
NCBI entrez gene - 14211     See in Manteia.
MGI - MGI:106067
RefSeq - NM_001301412
RefSeq - NM_008017
RefSeq Peptide - NP_001288341
RefSeq Peptide - NP_032043
swissprot - B1AWH6
swissprot - Q8CG48
Ensembl - ENSMUSG00000028312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc2ENSDARG00000017744Danio rerio
 SMC2ENSGALG00000015691Gallus gallus
 SMC2ENSG00000136824Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR010935  SMCs flexible hinge
 IPR024704  Structural maintenance of chromosomes protein
 IPR027120  Smc2, ATP-binding cassette domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036277  SMCs flexible hinge superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007076 mitotic chromosome condensation ISO
 biological_processGO:0010032 meiotic chromosome condensation IMP
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0045132 meiotic chromosome segregation IMP
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051383 kinetochore organization IMP
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000793 condensed chromosome ISO
 cellular_componentGO:0000796 condensin complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
Condensation of Prometaphase Chromosomes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

 MP:0012203 abnormal neuronal stem cell morphology "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0012204 abnormal neuronal stem cell physiology "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
Show

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr