ENSMUSG00000028479


Mus musculus

Features
Gene ID: ENSMUSG00000028479
  
Biological name :Gne
  
Synonyms : glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase / Gne / Q91WG8
  
Possible biological names infered from orthology : Q9Y223
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 44034075
Gene end: 44084177
  
Corresponding Affymetrix probe sets: 10512640 (MoGene1.0st)   1448810_at (Mouse Genome 430 2.0 Array)   1455583_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134406
Ensembl peptide - ENSMUSP00000030201
Ensembl peptide - ENSMUSP00000100000
Ensembl peptide - ENSMUSP00000115858
Ensembl peptide - ENSMUSP00000118443
Ensembl peptide - ENSMUSP00000122793
Ensembl peptide - ENSMUSP00000133440
Ensembl peptide - ENSMUSP00000133521
Ensembl peptide - ENSMUSP00000133551
Ensembl peptide - ENSMUSP00000134040
Ensembl peptide - ENSMUSP00000134191
NCBI entrez gene - 50798     See in Manteia.
MGI - MGI:1354951
RefSeq - XM_017320310
RefSeq - NM_001190414
RefSeq - NM_015828
RefSeq - XM_006538073
RefSeq - XM_006538074
RefSeq Peptide - NP_001177343
RefSeq Peptide - NP_056643
swissprot - G3UZ98
swissprot - F6WD11
swissprot - Q91WG8
swissprot - F6SHH4
swissprot - Q3TCI8
swissprot - Q3UW64
swissprot - F7BWW0
swissprot - G3UWV5
swissprot - G3UX23
swissprot - G3UYD5
swissprot - G3UX49
swissprot - G3UYR7
Ensembl - ENSMUSG00000028479
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gneENSDARG00000099771Danio rerio
 GNEENSGALG00000015331Gallus gallus
 GNEENSG00000159921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000600  ROK family
 IPR003331  UDP-N-acetylglucosamine 2-epimerase domain
 IPR020004  UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing
 IPR029767  UDP-N-acetylglucosamine 2-epimerase WecB-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006045 N-acetylglucosamine biosynthetic process IEA
 biological_processGO:0006047 UDP-N-acetylglucosamine metabolic process IEA
 biological_processGO:0006054 N-acetylneuraminate metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity ISS
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008761 UDP-N-acetylglucosamine 2-epimerase activity IEA
 molecular_functionGO:0009384 N-acylmannosamine kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm1.2Plag/Gnas+
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6 * CD-1 * SJL

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0008062 abnormal podocyte slit junction morphology "any structural anomaly in the gaps between the interdigitated foot processes of the podocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028479 Gne / Q91WG8 / glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase / Q9Y223*  / complex






 

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