ENSMUSG00000028517


Mus musculus

Features
Gene ID: ENSMUSG00000028517
  
Biological name :Plpp3
  
Synonyms : Phospholipid phosphatase 3 / Plpp3 / Q99JY8
  
Possible biological names infered from orthology : AC119674.2 / O14495
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 105157347
Gene end: 105232764
  
Corresponding Affymetrix probe sets: 10506488 (MoGene1.0st)   1429514_at (Mouse Genome 430 2.0 Array)   1448908_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065719
NCBI entrez gene - 67916     See in Manteia.
MGI - MGI:1915166
RefSeq - NM_080555
RefSeq Peptide - NP_542122
swissprot - Q99JY8
Ensembl - ENSMUSG00000028517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plpp3ENSDARG00000059933Danio rerio
 PLPP3ENSGALG00000010818Gallus gallus
 AC119674.2ENSG00000284686Homo sapiens
 PLPP3ENSG00000162407Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plpp2 / Q9DAX2 / phospholipid phosphatase 2 / O43688*ENSMUSG0000005215144
Plpp1 / Q61469 / Phospholipid phosphatase 1 / O14494*ENSMUSG0000002175941
Plppr4 / Q7TME0 / Phospholipid phosphatase-related protein type 4 / Q7Z2D5* / phospholipid phosphatase related 4*ENSMUSG0000004466726
Plppr3 / phospholipid phosphatase related 3 / Q6T4P5*ENSMUSG0000003583524
Plppr1 / Q8BFZ2 / Phospholipid phosphatase-related protein type 1 / Q8TBJ4* / phospholipid phosphatase related 1*ENSMUSG0000006344624
Plppr5 / Q8BJ52 / Phospholipid phosphatase-related protein type 5 / Q32ZL2* / phospholipid phosphatase related 5*ENSMUSG0000003334223
Plppr2 / Q8VCY8 / Phospholipid phosphatase-related protein type 2 / Q96GM1* / phospholipid phosphatase related 2*ENSMUSG0000004056322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR028675  Lipid phosphate phosphohydrolase 3
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0006644 phospholipid metabolic process IMP
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IDA
 biological_processGO:0034109 homotypic cell-cell adhesion ISO
 biological_processGO:0044328 canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration ISO
 biological_processGO:0044329 canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion ISO
 biological_processGO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing ISO
 biological_processGO:0046839 phospholipid dephosphorylation IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060020 Bergmann glial cell differentiation IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:1902068 regulation of sphingolipid mediated signaling pathway IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0008195 phosphatidate phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042392 sphingosine-1-phosphate phosphatase activity IMP
 molecular_functionGO:0042577 lipid phosphatase activity IMP


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+,Tg(CAG-EGFP)D4Nagy/0,Tg(Hmgcr-lacZ)H253Sest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Plpp3tm2Stw/Plpp3tm2Stw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0011256 abnormal neural fold morphology "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
Show

Allelic Composition: Plpp3tm3.1Stw/Plpp3tm3.1Stw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012181 increased somite number "increase in the average number of somites formed relative to littermates or other controls" [MGI:anna]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012274 increased axial mesoderm size "greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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