ENSG00000162407


Homo sapiens

Features
Gene ID: ENSG00000162407
  
Biological name :PLPP3
  
Synonyms : O14495 / phospholipid phosphatase 3 / PLPP3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.2
Gene start: 56494747
Gene end: 56645301
  
Corresponding Affymetrix probe sets: 209355_s_at (Human Genome U133 Plus 2.0 Array)   212226_s_at (Human Genome U133 Plus 2.0 Array)   212230_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360296
NCBI entrez gene - 8613     See in Manteia.
OMIM - 607125
RefSeq - NM_003713
RefSeq Peptide - NP_003704
swissprot - O14495
Ensembl - ENSG00000162407
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plpp3ENSDARG00000059933Danio rerio
 PLPP3ENSGALG00000010818Gallus gallus
 Plpp3ENSMUSG00000028517Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC119674.2ENSG0000028468661
PLPP1 / O14494 / phospholipid phosphatase 1ENSG0000006711344
PLPP2 / O43688 / phospholipid phosphatase 2ENSG0000014193442
PLPPR4 / Q7Z2D5 / phospholipid phosphatase related 4ENSG0000011760025
PLPPR1 / Q8TBJ4 / phospholipid phosphatase related 1ENSG0000014812324
PLPPR5 / Q32ZL2 / phospholipid phosphatase related 5ENSG0000011759823
PLPPR3 / Q6T4P5 / phospholipid phosphatase related 3ENSG0000012995123
PLPPR2 / Q96GM1 / phospholipid phosphatase related 2ENSG0000010552021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR028675  Lipid phosphate phosphohydrolase 3
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0006644 phospholipid metabolic process IBA
 biological_processGO:0008354 germ cell migration TAS
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0034109 homotypic cell-cell adhesion IDA
 biological_processGO:0044328 canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration IMP
 biological_processGO:0044329 canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion IMP
 biological_processGO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing IMP
 biological_processGO:0046839 phospholipid dephosphorylation IBA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005912 adherens junction TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008195 phosphatidate phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042392 sphingosine-1-phosphate phosphatase activity IBA
 molecular_functionGO:0042577 lipid phosphatase activity IBA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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