ENSG00000067113


Homo sapiens

Features
Gene ID: ENSG00000067113
  
Biological name :PLPP1
  
Synonyms : O14494 / phospholipid phosphatase 1 / PLPP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q11.2
Gene start: 55424854
Gene end: 55535050
  
Corresponding Affymetrix probe sets: 209147_s_at (Human Genome U133 Plus 2.0 Array)   210946_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264775
Ensembl peptide - ENSP00000425052
Ensembl peptide - ENSP00000302229
NCBI entrez gene - 8611     See in Manteia.
OMIM - 607124
RefSeq - XM_006714724
RefSeq - NM_003711
RefSeq - NM_176895
RefSeq Peptide - NP_003702
RefSeq Peptide - NP_795714
swissprot - O14494
swissprot - D6REC3
swissprot - A0A024QZU7
swissprot - A0A024QZS3
Ensembl - ENSG00000067113
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018102.1ENSDARG00000079790Danio rerio
 plpp1aENSDARG00000053381Danio rerio
 PLPP1ENSGALG00000014711Gallus gallus
 Plpp1ENSMUSG00000021759Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLPP2 / O43688 / phospholipid phosphatase 2ENSG0000014193454
PLPP3 / O14495 / phospholipid phosphatase 3ENSG0000016240748
AC119674.2ENSG0000028468637
PLPPR1 / Q8TBJ4 / phospholipid phosphatase related 1ENSG0000014812327
PLPPR4 / Q7Z2D5 / phospholipid phosphatase related 4ENSG0000011760027
PLPPR3 / Q6T4P5 / phospholipid phosphatase related 3ENSG0000012995126
PLPPR5 / Q32ZL2 / phospholipid phosphatase related 5ENSG0000011759824
PLPPR2 / Q96GM1 / phospholipid phosphatase related 2ENSG0000010552022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR028670  Lipid phosphate phosphohydrolase 1
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IBA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008285 negative regulation of cell proliferation NAS
 biological_processGO:0008354 germ cell migration TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019216 regulation of lipid metabolic process NAS
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway TAS
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0046839 phospholipid dephosphorylation TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0008195 phosphatidate phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042392 sphingosine-1-phosphate phosphatase activity TAS
 molecular_functionGO:0042577 lipid phosphatase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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