ENSMUSG00000028524


Mus musculus

Features
Gene ID: ENSMUSG00000028524
  
Biological name :Sgip1
  
Synonyms : Q8VD37 / Sgip1 / SH3-containing GRB2-like protein 3-interacting protein 1
  
Possible biological names infered from orthology : Q9BQI5 / SH3 domain GRB2 like endophilin interacting protein 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 102741297
Gene end: 102973628
  
Corresponding Affymetrix probe sets: 10506360 (MoGene1.0st)   1425180_at (Mouse Genome 430 2.0 Array)   1425181_at (Mouse Genome 430 2.0 Array)   1431300_at (Mouse Genome 430 2.0 Array)   1440655_at (Mouse Genome 430 2.0 Array)   1444225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139337
Ensembl peptide - ENSMUSP00000063712
Ensembl peptide - ENSMUSP00000072301
Ensembl peptide - ENSMUSP00000079553
Ensembl peptide - ENSMUSP00000102495
Ensembl peptide - ENSMUSP00000115075
Ensembl peptide - ENSMUSP00000122556
NCBI entrez gene - 73094     See in Manteia.
MGI - MGI:1920344
RefSeq - XM_017320404
RefSeq - XM_006503427
RefSeq - XM_006503428
RefSeq - XM_006503429
RefSeq - XM_006503430
RefSeq - XM_017320400
RefSeq - XM_017320401
RefSeq - XM_017320402
RefSeq - XM_017320403
RefSeq - NM_001285852
RefSeq - NM_001285859
RefSeq - NM_001285860
RefSeq - NM_001285862
RefSeq - NM_144906
RefSeq Peptide - NP_001272791
RefSeq Peptide - NP_001272781
RefSeq Peptide - NP_001272788
RefSeq Peptide - NP_659155
RefSeq Peptide - NP_001272789
swissprot - Q8VD37
swissprot - F7CPX0
swissprot - F6VMS8
Ensembl - ENSMUSG00000028524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgip1aENSDARG00000097897Danio rerio
 SGIP1ENSGALG00000011113Gallus gallus
 SGIP1ENSG00000118473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcho2 / Q3UQN2 / F-BAR domain only protein 2 / Q0JRZ9* / FCH domain only 2*ENSMUSG0000004168537
Fcho1 / Q8K285 / F-BAR domain only protein 1 / O14526* / FCH domain only 1*ENSMUSG0000007000024


Protein motifs (from Interpro)
Interpro ID Name
 IPR018808  Muniscin C-terminal
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002021 response to dietary excess ISS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IMP
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:0097320 plasma membrane tubulation IDA
 biological_processGO:2000253 positive regulation of feeding behavior ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0015631 tubulin binding IPI
 molecular_functionGO:0017124 SH3 domain binding ISO


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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