ENSMUSG00000028614


Mus musculus

Features
Gene ID: ENSMUSG00000028614
  
Biological name :Ndc1
  
Synonyms : Ndc1 / Nucleoporin NDC1 / Q8VCB1
  
Possible biological names infered from orthology : NDC1 transmembrane nucleoporin / Q9BTX1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107367784
Gene end: 107416346
  
Corresponding Affymetrix probe sets: 10506680 (MoGene1.0st)   1424173_at (Mouse Genome 430 2.0 Array)   1433813_at (Mouse Genome 430 2.0 Array)   1460353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120365
Ensembl peptide - ENSMUSP00000136239
Ensembl peptide - ENSMUSP00000136850
Ensembl peptide - ENSMUSP00000137180
NCBI entrez gene - 72787     See in Manteia.
MGI - MGI:1920037
RefSeq - XM_006503423
RefSeq - NM_028355
RefSeq Peptide - NP_082631
swissprot - J3QMD9
swissprot - Q8VCB1
swissprot - J3QPB5
Ensembl - ENSMUSG00000028614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndc1ENSDARG00000021120Danio rerio
 NDC1ENSGALG00000031606Gallus gallus
 NDC1ENSG00000058804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019049  Nucleoporin protein Ndc1-Nup


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006999 nuclear pore organization IBA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031081 nuclear pore distribution IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051292 nuclear pore complex assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0070762 nuclear pore transmembrane ring IBA
 molecular_functionGO:0017056 structural constituent of nuclear pore IEA


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptpn11tm7Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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