ENSMUSG00000028684


Mus musculus

Features
Gene ID: ENSMUSG00000028684
  
Biological name :Urod
  
Synonyms : P70697 / Urod / uroporphyrinogen decarboxylase
  
Possible biological names infered from orthology : P06132
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 116989965
Gene end: 116994413
  
Corresponding Affymetrix probe sets: 10515385 (MoGene1.0st)   1417206_at (Mouse Genome 430 2.0 Array)   1443849_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030446
Ensembl peptide - ENSMUSP00000116154
NCBI entrez gene - 22275     See in Manteia.
MGI - MGI:98916
RefSeq - XM_006502932
RefSeq - NM_009478
RefSeq - XM_006502931
RefSeq Peptide - NP_033504
swissprot - P70697
swissprot - A0A0A0MQG7
Ensembl - ENSMUSG00000028684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 urodENSDARG00000006818Danio rerio
 ENSGALG00000010219Gallus gallus
 URODENSG00000126088Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000257  Uroporphyrinogen decarboxylase (URO-D)
 IPR006361  Uroporphyrinogen decarboxylase HemE


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process IMP
 biological_processGO:0042168 heme metabolic process IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004853 uroporphyrinogen decarboxylase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

 MP:0004147 increased porphyrin level "elevated concentration of porphyrins or protoporphyrins" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfetm2Nca/Hfetm2Nca,Urodtm1Kush/Urod+
Genetic Background: involves: C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028684 Urod / P70697 / uroporphyrinogen decarboxylase / P06132*  / complex






 

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