ENSMUSG00000028882


Mus musculus

Features
Gene ID: ENSMUSG00000028882
  
Biological name :Ppp1r8
  
Synonyms : Nuclear inhibitor of protein phosphatase 1 / Ppp1r8 / Q8R3G1
  
Possible biological names infered from orthology : protein phosphatase 1 regulatory subunit 8 / Q12972
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132826929
Gene end: 132843169
  
Corresponding Affymetrix probe sets: 10516974 (MoGene1.0st)   1424554_at (Mouse Genome 430 2.0 Array)   1435821_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030702
Ensembl peptide - ENSMUSP00000101539
NCBI entrez gene - 100336     See in Manteia.
MGI - MGI:2140494
RefSeq - XM_006538465
RefSeq - NM_001290725
RefSeq - NM_146154
RefSeq - XM_006538464
RefSeq Peptide - NP_666266
RefSeq Peptide - NP_001277654
swissprot - Q8R3G1
swissprot - A2ADR8
Ensembl - ENSMUSG00000028882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r8aENSDARG00000007186Danio rerio
 ppp1r8bENSDARG00000022430Danio rerio
 PPP1R8ENSGALG00000000729Gallus gallus
 PPP1R8ENSG00000117751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc4a1ap / solute carrier family 4 (anion exchanger), member 1, adaptor protein / Q9BWU0* / solute carrier family 4 member 1 adaptor protein*ENSMUSG0000002914123
Snip1 / Q8BIZ6 / Smad nuclear-interacting protein 1 / Q8TAD8*ENSMUSG0000005021311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR008984  SMAD/FHA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0035308 negative regulation of protein dephosphorylation IBA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0016607 nuclear speck IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0004865 protein serine/threonine phosphatase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001717 absent ectoplacental cone 
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010040 abnormal oval cell morphology "any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0011208 small proamniotic cavity "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0014233 bile duct epithelium hyperplasia 
Show

Allelic Composition: Cdh2312J/Cdh2312J
Genetic Background: involves: C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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