ENSMUSG00000028946


Mus musculus

Features
Gene ID: ENSMUSG00000028946
  
Biological name :Hes3
  
Synonyms : Hes3 / hes family bHLH transcription factor 3 / Q61657
  
Possible biological names infered from orthology : Q5TGS1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 152285972
Gene end: 152291662
  
Corresponding Affymetrix probe sets: 10518902 (MoGene1.0st)   1422409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092006
Ensembl peptide - ENSMUSP00000151815
NCBI entrez gene - 15207     See in Manteia.
MGI - MGI:104877
RefSeq - XM_017319983
RefSeq - NM_008237
RefSeq - XM_011250192
RefSeq - XM_011250193
RefSeq - XM_011250194
RefSeq - XM_006538550
RefSeq - XM_006538560
RefSeq - XM_011250189
RefSeq - XM_011250190
RefSeq - XM_011250191
RefSeq Peptide - NP_032263
swissprot - Q61657
swissprot - A0A1W2P7Y8
Ensembl - ENSMUSG00000028946
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 her3ENSDARG00000076857Danio rerio
 HES3ENSG00000173673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis IGI
 biological_processGO:0021557 oculomotor nerve development IGI
 biological_processGO:0021558 trochlear nerve development IGI
 biological_processGO:0021575 hindbrain morphogenesis IGI
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050767 regulation of neurogenesis IGI
 biological_processGO:0060164 regulation of timing of neuron differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001062 absent oculomotor nerve "missing nerve of the extraocular muscles, iris and ciliary body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001064 absent trochlear nerve "missing nerve of the superior oblique muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acvr2btm1Enl/Acvr2btm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004280 abnormal oculomotor nucleus morphology "any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008949 increased Cajal-Retzius cell number "greater number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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