ENSMUSG00000028988


Mus musculus

Features
Gene ID: ENSMUSG00000028988
  
Biological name :Ctnnbip1
  
Synonyms : Beta-catenin-interacting protein 1 / Ctnnbip1 / Q9JJN6
  
Possible biological names infered from orthology : catenin beta interacting protein 1 / Q9NSA3
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 149518236
Gene end: 149566437
  
Corresponding Affymetrix probe sets: 10510473 (MoGene1.0st)   1417567_at (Mouse Genome 430 2.0 Array)   1431694_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030839
Ensembl peptide - ENSMUSP00000101317
NCBI entrez gene - 67087     See in Manteia.
MGI - MGI:1915756
RefSeq - NM_001141930
RefSeq - NM_023465
RefSeq Peptide - NP_001135402
RefSeq Peptide - NP_075954
swissprot - Q9JJN6
Ensembl - ENSMUSG00000028988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctnnbip1ENSDARG00000038954Danio rerio
 CTNNBIP1ENSGALG00000026306Gallus gallus
 Q9NSA3ENSG00000178585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lzic / Q8K3C3 / Protein LZIC / Q8WZA0* / leucine zipper and CTNNBIP1 domain containing*ENSMUSG0000002899035


Protein motifs (from Interpro)
Interpro ID Name
 IPR009428  Beta-catenin-interacting ICAT
 IPR036911  Beta-catenin-interacting ICAT superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0002528 regulation of vascular permeability involved in acute inflammatory response ISO
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0016055 Wnt signaling pathway IPI
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0031333 negative regulation of protein complex assembly IDA
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045657 positive regulation of monocyte differentiation ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IMP
 biological_processGO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter IDA
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation ISO
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030877 beta-catenin destruction complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0070016 armadillo repeat domain binding ISO


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0003604 single kidney 
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction






 

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