ENSMUSG00000029093


Mus musculus

Features
Gene ID: ENSMUSG00000029093
  
Biological name :Sorcs2
  
Synonyms : Q9EPR5 / Sorcs2 / sortilin-related VPS10 domain containing receptor 2
  
Possible biological names infered from orthology : Q96PQ0
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 36017180
Gene end: 36398139
  
Corresponding Affymetrix probe sets: 10529515 (MoGene1.0st)   1419358_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123543
Ensembl peptide - ENSMUSP00000041828
Ensembl peptide - ENSMUSP00000065292
NCBI entrez gene - 81840     See in Manteia.
MGI - MGI:1932289
RefSeq - NM_030889
RefSeq - XM_006504202
RefSeq Peptide - NP_112151
swissprot - D3YYF4
swissprot - Q8BI74
swissprot - Q9EPR5
Ensembl - ENSMUSG00000029093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sorcs2ENSDARG00000077465Danio rerio
 SORCS2ENSGALG00000015554Gallus gallus
 Q96PQ0ENSG00000184985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VI51 / Sorcs3 / VPS10 domain-containing receptor SorCS3 / Q9UPU3* / sortilin related VPS10 domain containing receptor 3*ENSMUSG0000006343443
Sorcs1 / sortilin related VPS10 domain containing receptor 1 / Q8WY21*ENSMUSG0000004353142
Sorl1 / O88307 / Sortilin-related receptor / Q92673* / sortilin related receptor 1*ENSMUSG0000004931323
Sort1 / Q6PHU5 / Sortilin / Q99523* / sortilin 1*ENSMUSG0000006874718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR006581  VPS10
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031777  Sortilin, C-terminal
 IPR031778  Sortilin, N-terminal
 IPR035986  PKD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah5b2b3491Clo/Dnah5b2b3491Clo
Genetic Background: C57BL/6J-Dnah5b2b3491Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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