ENSMUSG00000029104


Mus musculus

Features
Gene ID: ENSMUSG00000029104
  
Biological name :Htt
  
Synonyms : Htt / huntingtin
  
Possible biological names infered from orthology : P42858
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 34761740
Gene end: 34912534
  
Corresponding Affymetrix probe sets: 10521261 (MoGene1.0st)   1425969_a_at (Mouse Genome 430 2.0 Array)   1435539_at (Mouse Genome 430 2.0 Array)   1446337_at (Mouse Genome 430 2.0 Array)   1456667_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078945
NCBI entrez gene - 15194     See in Manteia.
MGI - MGI:96067
RefSeq - XM_017320683
RefSeq - NM_010414
RefSeq - XM_006503744
RefSeq Peptide - NP_034544
swissprot - G3X9H5
Ensembl - ENSMUSG00000029104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 httENSDARG00000052866Danio rerio
 HTTENSGALG00000015635Gallus gallus
 HTTENSG00000197386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000091  Huntingtin
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024613  Huntingtin, middle-repeat
 IPR028426  Huntingtin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042297 vocal learning IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045724 positive regulation of cilium assembly IEA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1904504 positive regulation of lipophagy IEA
 biological_processGO:1905337 positive regulation of aggrephagy IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005522 profilin binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0034452 dynactin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045505 dynein intermediate chain binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000022 abnormal ear shape "malformation of the pattern of the external ear" [J:65038]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

 MP:0000440 domed skull 
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Htttm2.1Pfs/Htt+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000778 abnormal tract 
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000835 abnormal subthalamic nucleus morphology "any malformation or absence of the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Sox13tm1Jskg/Sox13+
Genetic Background: involves: C57BL/6

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: STOCK Htttm5Mem/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htttm1Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm6Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm1Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Htttm2.1Pfs/Htt+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0001400 hyperresponsive "increased reaction to touch" [J:39801]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Htttm3Szi/Htt+
Genetic Background: involves: 129S1/Sv

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: STOCK Htttm5Mem/J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htttm1Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Hap1tm1Id/Hap1tm1Id,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Hap1tm1Id/Hap1+,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dppa2tm1.1Yam/Dppa2tm1.1Yam,Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC46)668Hay/0
Genetic Background: involves: FVB/N

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm6Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm1Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Htttm4Szi/Htttm5Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

Allelic Composition: Htttm4Szi/Htttm4Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elntm1Dyl/Eln+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Htttm4Szi/Htttm5Szi
Genetic Background: involves: 129S1/Sv

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

Allelic Composition: Htttm1Hay/Htt+,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htttm1Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm1.1Tna/Htttm1.1Tna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1.1Tna/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm3Szi/Htttm3Szi
Genetic Background: involves: 129S1/Sv

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm4Szi/Htttm5Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

Allelic Composition: Htttm4Szi/Htttm4Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Detl/Htttm1Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm4Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mfc/Htt+,Ppargc1atm1Dpk/Ppargc1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004081 abnormal globus pallidus morphology "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htttm1Hay/Htt+
Genetic Background: involves: C57BL/6J

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004103 abnormal ventral striatum morphology "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm4Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htt+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htttm2Detl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0005499 abnormal olfactory system morphology "anomalous structure of the organs involved in smell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hap1tm1Id/Hap1tm1Id,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Hap1tm1Id/Hap1+,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Htttm4Szi/Htttm5Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

Allelic Composition: Htttm4Szi/Htttm4Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Szi/Htttm2Szi,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
Show

Allelic Composition: Htttm4Mem/Htttm4Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm4Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Allelic Composition: Htttm1Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0009324 absent hippocampal fimbria "absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.464.265, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Htttm7Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Htttm4Szi/Htttm5Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

Allelic Composition: Htttm4Szi/Htttm4Szi,Tg(Hsp70-1-cre)1Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Htttm1Mem/Htttm6Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay
Genetic Background: involves: C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Htttm1Mem/Htttm7Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0012095 increased Reichert s membrane thickness "increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0012104 small amniotic cavity "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0012165 absent neural folds "absence of the elevated margins of the neural groove" [MGI:csmith]
Show

Allelic Composition: Hap1tm1Id/Hap1tm1Id,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Hap1tm1Id/Hap1+,Htttm1Szi/Htttm1Szi
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(HTT*97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay
Genetic Background: FVB.Cg-Htttm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

 MP:0012506 brain atrophy "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0020070 decreased neocortex volume "decrease from the average range of neocortex volume compared to normal" [GOC:NV]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0020214 susceptible to malignant hyperthermia "increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine" [GOC:NV, http://en.wikipedia.org/wiki/Malignant_hyperthermia]
Show

Allelic Composition: Htttm6Mem/Htttm8Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC72)2511Hay/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr