ENSMUSG00000029507


Mus musculus

Features
Gene ID: ENSMUSG00000029507
  
Biological name :Pus1
  
Synonyms : Mus musculus pseudouridine synthase 1 (Pus1), transcript variant 6, mRNA. / Pus1 / Q9WU56
  
Possible biological names infered from orthology : pseudouridylate synthase 1 / Q9Y606
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 110773667
Gene end: 110780659
  
Corresponding Affymetrix probe sets: 10532463 (MoGene1.0st)   1418869_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115468
Ensembl peptide - ENSMUSP00000115143
Ensembl peptide - ENSMUSP00000130814
Ensembl peptide - ENSMUSP00000031481
Ensembl peptide - ENSMUSP00000031483
Ensembl peptide - ENSMUSP00000083844
Ensembl peptide - ENSMUSP00000108045
NCBI entrez gene - 56361     See in Manteia.
MGI - MGI:1929237
RefSeq - XM_017321015
RefSeq - NM_001025561
RefSeq - NM_001025562
RefSeq - NM_001347390
RefSeq - NM_001359219
RefSeq - NM_019700
RefSeq - XM_006535148
RefSeq - XM_006535149
RefSeq - XM_011249545
RefSeq - XM_017321014
RefSeq Peptide - NP_001020733
RefSeq Peptide - NP_001334319
RefSeq Peptide - NP_001346148
RefSeq Peptide - NP_062674
RefSeq Peptide - NP_001020732
swissprot - D3Z092
swissprot - Q9WU56
swissprot - D3YWU8
swissprot - H7BX59
Ensembl - ENSMUSG00000029507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pus1ENSDARG00000045562Danio rerio
 PUS1ENSGALG00000002354Gallus gallus
 PUS1ENSG00000177192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001406  Pseudouridine synthase I, TruA
 IPR020095  Pseudouridine synthase I, TruA, C-terminal
 IPR020097  Pseudouridine synthase I, TruA, alpha/beta domain
 IPR020103  Pseudouridine synthase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001522 pseudouridine synthesis IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0009451 RNA modification IEA
 biological_processGO:0031119 tRNA pseudouridine synthesis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1990481 mRNA pseudouridine synthesis IBA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009982 pseudouridine synthase activity ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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