ENSMUSG00000029553


Mus musculus

Features
Gene ID: ENSMUSG00000029553
  
Biological name :Tfec
  
Synonyms : Q9WTW4 / Tfec / Transcription factor EC
  
Possible biological names infered from orthology : O14948
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A2
Gene start: 16833373
Gene end: 16898441
  
Corresponding Affymetrix probe sets: 10543239 (MoGene1.0st)   1419537_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144445
Ensembl peptide - ENSMUSP00000031533
Ensembl peptide - ENSMUSP00000143880
NCBI entrez gene - 21426     See in Manteia.
MGI - MGI:1333760
RefSeq - XM_017321504
RefSeq - XM_006505035
RefSeq - XM_006505036
RefSeq - XM_006505037
RefSeq - XM_011241053
RefSeq - NM_031198
RefSeq Peptide - NP_112475
swissprot - A0A0J9YV19
swissprot - A0A0J9YTW5
swissprot - Q9WTW4
Ensembl - ENSMUSG00000029553
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfecENSDARG00000098745Danio rerio
 TFECENSGALG00000040557Gallus gallus
 TFECENSG00000105967Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mitf / Q08874 / melanogenesis associated transcription factor / O75030*ENSMUSG0000003515844
Tfe3 / Q64092 / Transcription factor E3 / P19532* / transcription factor binding to IGHM enhancer 3*ENSMUSG0000000013444
Tfeb / Q9R210 / transcription factor EB / P19484*ENSMUSG0000002399042


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR021802  MiT/TFE transcription factors, C-terminal
 IPR024101  Transcription factor EC
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: MitfMi/MitfMi,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: MitfMi-wh/MitfMi-wh,Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Allelic Composition: MitfMi/MitfMi,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: MitfMi-wh/MitfMi-wh,Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Kudo/Cd9tm1Kudo
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Tfebtm1Est/Tfeb+,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005171 lack of coat pigmentation "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Allelic Composition: MitfMi/MitfMi,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: MitfMi-wh/MitfMi-wh,Tfe3tm1Est/Tfe3tm1Est,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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