ENSG00000105967


Homo sapiens

Features
Gene ID: ENSG00000105967
  
Biological name :TFEC
  
Synonyms : O14948 / TFEC / transcription factor EC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.2
Gene start: 115935148
Gene end: 116159896
  
Corresponding Affymetrix probe sets: 206715_at (Human Genome U133 Plus 2.0 Array)   232383_at (Human Genome U133 Plus 2.0 Array)   236995_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265440
Ensembl peptide - ENSP00000377125
Ensembl peptide - ENSP00000387650
Ensembl peptide - ENSP00000417432
Ensembl peptide - ENSP00000318676
NCBI entrez gene - 22797     See in Manteia.
OMIM - 604732
RefSeq - XM_017011878
RefSeq - NM_001018058
RefSeq - NM_001244583
RefSeq - NM_012252
RefSeq - XM_011515972
RefSeq - XM_017011874
RefSeq - XM_017011875
RefSeq - XM_017011876
RefSeq - XM_017011877
RefSeq - XM_011515963
RefSeq - XM_011515964
RefSeq - XM_011515965
RefSeq - XM_011515966
RefSeq - XM_011515969
RefSeq - XM_011515970
RefSeq Peptide - NP_001018068
RefSeq Peptide - NP_001231512
RefSeq Peptide - NP_036384
swissprot - O14948
swissprot - B7Z757
Ensembl - ENSG00000105967
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfecENSDARG00000098745Danio rerio
 TFECENSGALG00000040557Gallus gallus
 TfecENSMUSG00000029553Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MITF / O75030 / melanogenesis associated transcription factorENSG0000018709848
TFE3 / P19532 / transcription factor binding to IGHM enhancer 3ENSG0000006832345
TFEB / P19484 / transcription factor EBENSG0000011256143


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR021802  MiT/TFE transcription factors, C-terminal
 IPR024101  Transcription factor EC
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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