Manteia

ENSG00000112561

Homo sapiens

Features

Gene ID:	ENSG00000112561

Biological name :	TFEB

Synonyms :	P19484 / TFEB / transcription factor EB

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	6
Strand:	-1
Band:	p21.1
Gene start:	41683978
Gene end:	41736259

Corresponding Affymetrix probe sets:	221866_at (Human Genome U133 Plus 2.0 Array) 50221_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000383998 Ensembl peptide - ENSP00000377824 Ensembl peptide - ENSP00000384203 Ensembl peptide - ENSP00000415946 Ensembl peptide - ENSP00000415035 Ensembl peptide - ENSP00000412551 Ensembl peptide - ENSP00000410391 Ensembl peptide - ENSP00000406491 Ensembl peptide - ENSP00000400276 Ensembl peptide - ENSP00000396168 Ensembl peptide - ENSP00000395208 Ensembl peptide - ENSP00000393874 Ensembl peptide - ENSP00000230323 Ensembl peptide - ENSP00000343948 Ensembl peptide - ENSP00000351742 Ensembl peptide - ENSP00000362124 NCBI entrez gene - 7942 See in Manteia. OMIM - 600744 RefSeq - XM_011514916 RefSeq - NM_001167827 RefSeq - NM_001271943 RefSeq - NM_001271944 RefSeq - NM_001271945 RefSeq - NM_007162 RefSeq - XM_005249411 RefSeq - XM_005249412 RefSeq - XM_006715212 RefSeq - XM_006715213 RefSeq - XM_011514915 RefSeq Peptide - NP_001258872 RefSeq Peptide - NP_001258873 RefSeq Peptide - NP_001258874 RefSeq Peptide - NP_001161299 RefSeq Peptide - NP_009093 swissprot - P19484 swissprot - B1AKB2 swissprot - B1AKB1 swissprot - B1AKA9 swissprot - B1AKA7 swissprot - B0QYS7 swissprot - B0QYS6 swissprot - A0A1B0GXL9 swissprot - B1AKB4 swissprot - Q709A8 swissprot - Q709A9 swissprot - A0A024RCY3 swissprot - B1AKB5 Ensembl - ENSG00000112561

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tfeb	ENSDARG00000010794	Danio rerio
TFEB	ENSGALG00000039878	Gallus gallus
Tfeb	ENSMUSG00000023990	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
TFE3 / P19532 / transcription factor binding to IGHM enhancer 3	ENSG00000068323	45
MITF / O75030 / melanogenesis associated transcription factor	ENSG00000187098	45
TFEC / O14948 / transcription factor EC	ENSG00000105967	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR021802	MiT/TFE transcription factors, C-terminal
IPR024098	Transcription factor EB
IPR031867	MiT/TFE transcription factors, N-terminal
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001892	embryonic placenta development	ISS
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	NAS
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0006959	humoral immune response	ISS
biological_process	GO:0007040	lysosome organization	IMP
biological_process	GO:0010508	positive regulation of autophagy	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
cellular_component	GO:0005634	nucleus	NAS
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	NAS
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	NAS
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IDA
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr